Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0ZE9C
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| Former ID |
DIB001153
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| Drug Name |
PAZINACLONE
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| Synonyms |
A-77000; DN-2327; Pazinaclone < Rec INN; Rac-8-[[2-(7-Chloro-1,8-naphthyridin-2-yl)-2,3-dihydro-3-oxo-1H-isoindol-1-yl]acetyl]-1,4-dioxa-8-azaspiro[4.5]decane
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| Drug Type |
Small molecular drug
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| Indication | Anxiety disorder [ICD9: 300, 311; ICD10:F32, F40-F42] | Discontinued in Phase 3 | [1] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C25H23ClN4O4
|
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| Canonical SMILES |
Clc1ccc2ccc(nc2n1)N3C(CC(=O)N4CCC5(CC4)OCCO5)C6C=CC=CC6<br />C3=O
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| InChI |
1S/C25H25ClN4O4/c26-20-7-5-16-6-8-21(28-23(16)27-20)30-19(17-3-1-2-4-18(17)24(30)32)15-22(31)29-11-9-25(10-12-29)33-13-14-34-25/h1-8,17-19H,9-15H2
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| InChIKey |
ODCORAJVSLDYFP-UHFFFAOYSA-N
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| CAS Number |
CAS 103255-66-9
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | GABA A receptor | Target Info | Modulator | [2] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
| Retrograde endocannabinoid signaling | |||||
| GABAergic synapse | |||||
| Morphine addiction | |||||
| Nicotine addiction | |||||
| Reactome | Ligand-gated ion channel transport | ||||
| GABA A receptor activation | |||||
| WikiPathways | SIDS Susceptibility Pathways | ||||
| Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | |||||
| Iron uptake and transport | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000717) | ||||
| REF 2 | The benzodiazepine binding site of GABA(A) receptors as a target for the development of novel anxiolytics. Expert Opin Investig Drugs. 2005 May;14(5):601-18. | ||||
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