Drug General Information
Drug ID	D0ZK7B
Former ID	DIB006312
Drug Name	Tesofensine
Synonyms	NS-2330
Drug Type	Small molecular drug
Indication	Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89]		Phase 2	[521678]
Company	NeuroSearch A/S
Structure		Download 2D MOL 3D MOL
Formula	C17H23Cl2NO
CAS Number	CAS 195875-84-4
PubChem Compound ID	11370864
Target and Pathway
Target(s)	Insulin receptor	Target Info	Inhibitor	[530847]
KEGG Pathway	Ras signaling pathway
	Rap1 signaling pathway
	cGMP-PKG signaling pathway
	HIF-1 signaling pathway
	FoxO signaling pathway
	PI3K-Akt signaling pathway
	AMPK signaling pathway
	Adherens junction
	Insulin signaling pathway
	Ovarian steroidogenesis
	Type II diabetes mellitus
	Non-alcoholic fatty liver disease (NAFLD)
	Aldosterone-regulated sodium reabsorption
NetPath Pathway	TGF_beta_Receptor Signaling Pathway
PANTHER Pathway	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
	Insulin/IGF pathway-protein kinase B signaling cascade
	PI3 kinase pathway
Pathway Interaction Database	Insulin Pathway
	Signaling events mediated by PTP1B
	Signaling events mediated by TCPTP
	Insulin-mediated glucose transport
PathWhiz Pathway	Insulin Signalling
	Leucine Stimulation on Insulin Signaling
Reactome	IRS activation
	Signal attenuation
	Insulin receptor signalling cascade
	Insulin receptor recycling
WikiPathways	DNA Damage Response (only ATM dependent)
	Insulin Signaling
	Nanoparticle triggered autophagic cell death
	AGE/RAGE pathway
	Signaling by Insulin receptor
	Folate Metabolism
	Type II diabetes mellitus
	Vitamin B12 Metabolism
	Selenium Micronutrient Network
	AMPK Signaling
References
Ref 521678	ClinicalTrials.gov (NCT00153010) An Evaluation of Three Doses of NS 2330 in Patients With Mild to Moderate Dementia of the Alzheimer's Type. U.S. National Institutes of Health.
Ref 530847	The novel triple monoamine reuptake inhibitor tesofensine induces sustained weight loss and improves glycemic control in the diet-induced obese rat: comparison to sibutramine and rimonabant. Eur J Pharmacol. 2010 Jun 25;636(1-3):88-95.

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