Drug Information

Drug General Information
Drug ID
D0ZL2A
Former ID
DIB020424
Drug Name
MRS1523
Synonyms
MRS 1523 ; MRS-1523
Drug Type
Small molecular drug
Indication Discovery agent Investigative [467982]
Structure
Download
2D MOL
Formula
C23H29NO3S
InChI
InChI=1S/C23H29NO3S/c1-5-12-17-19(23(26)28-8-4)18(7-3)24-21(16-13-10-9-11-14-16)20(17)22(25)27-15-6-2/h9-11,13-14H,5-8,12,15H2,1-4H3
InChIKey
UUSHFEVEROROSP-UHFFFAOYSA-N
PubChem Compound ID
3661570
PubChem Substance ID
4997151, 7980038, 9831048, 11111434, 14830456, 17405344, 24278127, 37856319, 47424236, 50106609, 50106610, 53777889, 56463618, 57356468, 78734149, 85209691, 85231127, 90341403, 92098501, 92304078, 103329922, 103967442, 112060444, 121361692, 124749996, 124800903, 124880654, 126261098, 129423418, 135650652, 162228389, 163122841, 163564737, 170474555, 178127095, 179235821, 204366635, 232101073, 252160708
Target and Pathway
Target(s) Adenosine A2b receptor Target Info Antagonist [543534]
Adenosine A1 receptor Target Info Antagonist [543488]
Adenosine A3 receptor Target Info Antagonist [534684]
KEGG Pathway Rap1 signaling pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Alcoholismhsa04022:cGMP-PKG signaling pathway
cAMP signaling pathway
Sphingolipid signaling pathway
Morphine addiction
NetPath Pathway TGF_beta_Receptor Signaling Pathway
TCR Signaling PathwayNetPath_11:TCR Signaling Pathway
RANKL Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Pathway Interaction Database C-MYB transcription factor network
PathWhiz Pathway Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
Reactome Adenosine P1 receptors
G alpha (s) signalling events
Surfactant metabolismR-HSA-417973:Adenosine P1 receptors
G alpha (i) signalling eventsR-HSA-417973:Adenosine P1 receptors
G alpha (i) signalling events
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP80:Nucleotide GPCRs
GPCRs, Other
References
Ref 467982(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 474).
Ref 534684Structure-activity relationships and molecular modeling of 3, 5-diacyl-2,4-dialkylpyridine derivatives as selective A3 adenosine receptor antagonists. J Med Chem. 1998 Aug 13;41(17):3186-201.
Ref 543488(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 18).
Ref 543534(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 20).

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