Drug Information

Drug General Information
Drug ID
D0ZU0O
Former ID
DIB020937
Drug Name
SEW2871
Synonyms
SEW-2871; SEW 2871
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539943]
Structure
Download
2D MOL
Formula
C20H10F6N2OS
InChI
InChI=1S/C20H10F6N2OS/c21-19(22,23)13-8-4-7-12(9-13)17-27-18(29-28-17)15-10-14(11-5-2-1-3-6-11)16(30-15)20(24,25)26/h1-10H
InChIKey
OYMNPJXKQVTQTR-UHFFFAOYSA-N
PubChem Compound ID
4077460
PubChem Substance ID
5991930, 9456564, 11538029, 24724607, 26540369, 26733769, 26753263, 26759552, 29215134, 35336212, 52640628, 53800523, 57356722, 71487884, 83100677, 85788696, 87624173, 99214894, 103512955, 104045123, 112614440, 118046685, 125335092, 126644833, 126666559, 135651038, 135697956, 141731683, 144104724, 151992558, 162023226, 162064813, 162088571, 162147084, 162991996, 163687303, 164225030, 164787849, 184529477, 184569849, 201504341, 204360395, 208264744, 223518277, 223542735, 223666151, 226759529, 246269603, 252156411, 252160351
Target and Pathway
Target(s) Sphingosine 1-phosphate receptor 1 Target Info Agonist [526934]
KEGG Pathway FoxO signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interaction
NetPath Pathway IL4 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
IL2 Signaling Pathway
Pathway Interaction Database Fc-epsilon receptor I signaling in mast cells
S1P3 pathway
S1P1 pathway
Sphingosine 1-phosphate (S1P) pathway
PDGFR-beta signaling pathway
Reactome G alpha (i) signalling events
Lysosphingolipid and LPA receptors
WikiPathways Signal Transduction of S1P Receptor
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 539943(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2926).
Ref 526934Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate. J Biol Chem. 2004 Apr 2;279(14):13839-48. Epub 2004 Jan 19.

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