Drug General Information
Drug ID	D0ZZ9M
Former ID	DNC000165
Drug Name	AF150(S)
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[535833], [536601]
Structure		Download 2D MOL 3D MOL
Formula	C9H16N2S
Canonical SMILES	CC1=NCC2(S1)CCN(CC2)C
InChI	1S/C9H16N2S/c1-8-10-7-9(12-8)3-5-11(2)6-4-9/h3-7H2,1-2H3
InChIKey	VGGGBQVTSUMURJ-UHFFFAOYSA-N
PubChem Compound ID	10176415
PubChem Substance ID	15171401, 22572248, 40265996, 79559897, 85214658, 134339677, 139119570, 224546012, 227549929, 243836909
Target and Pathway
Target(s)	Muscarinic acetylcholine receptor M1	Target Info	Agonist	[535833], [536601]
KEGG Pathway	Calcium signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	PI3K-Akt signaling pathway
	Cholinergic synapse
	Regulation of actin cytoskeleton
PANTHER Pathway	Alzheimer disease-amyloid secretase pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Reactome	Muscarinic acetylcholine receptors
	G alpha (q) signalling events
WikiPathways	Monoamine GPCRs
	Calcium Regulation in the Cardiac Cell
	Regulation of Actin Cytoskeleton
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Secretion of Hydrochloric Acid in Parietal Cells
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 535833	M1 muscarinic agonists can modulate some of the hallmarks in Alzheimer's disease: implications in future therapy. J Mol Neurosci. 2003;20(3):349-56.
Ref 536601	M1 muscarinic agonists target major hallmarks of Alzheimer's disease--an update. Curr Alzheimer Res. 2007 Dec;4(5):577-80.
Ref 535833	M1 muscarinic agonists can modulate some of the hallmarks in Alzheimer's disease: implications in future therapy. J Mol Neurosci. 2003;20(3):349-56.
Ref 536601	M1 muscarinic agonists target major hallmarks of Alzheimer's disease--an update. Curr Alzheimer Res. 2007 Dec;4(5):577-80.

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