Resistance mutation info of target

Target General Information
Target ID T13491
Target Name Equilibrative nucleoside transporter 1 (SLC29A1) Target Info
Gene Name SLC29A1
Species Homo sapiens
Uniprot ID S29A1_HUMAN
Sequence MTTSHQPQDRYKAVWLIFFMLGLGTLLPWNFFMTATQYFTNRLDMSQNVSLVTAELSKDA
QASAAPAAPLPERNSLSAIFNNVMTLCAMLPLLLFTYLNSFLHQRIPQSVRILGSLVAIL
LVFLITAILVKVQLDALPFFVITMIKIVLINSFGAILQGSLFGLAGLLPASYTAPIMSGQ
GLAGFFASVAMICAIASGSELSESAFGYFITACAVIILTIICYLGLPRLEFYRYYQQLKL
EGPGEQETKLDLISKGEEPRAGKEESGVSVSNSQPTNESHSIKAILKNISVLAFSVCFIF
TITIGMFPAVTVEVKSSIAGSSTWERYFIPVSCFLTFNIFDWLGRSLTAVFMWPGKDSRW
LPSLVLARLVFVPLLLLCNIKPRRYLTVVFEHDAWFIFFMAAFAFSNGYLASLCMCFGPK
KVKPAEAETAGAIMAFFLCLGLALGAVFSFLFRAIV [Homo sapiens]
Drug Resistance Mutation and Corresponding Drugs
Ref 468059(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4827).
Ref 530906Incorporation of gemcitabine and cytarabine into DNA by DNA polymerase beta and ligase III/XRCC1. Biochemistry. 2010 Jun 15;49(23):4833-40.
Ref 538237FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 071471.
Mutation Info Missense: G24R
Drugs
Drug Name Cytarabine (Ara-C) Drug Info [1559250]
Targeted Disease T cell leukemia
Reference
Ref 1559250Identification of a novel point mutation in ENT1 that confers resistance to Ara-C in human T cell leukemia CCRF-CEM cells.FEBS Lett.2009 Jan 22;583(2):425-9.

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