Resistance mutation info of target
| Target General Information | ||||||||||||||||||
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| Target ID | T52227 | |||||||||||||||||
| Target Name | Bacterial Thymidylate synthase (thyA) | Target Info | ||||||||||||||||
| Gene Name | thyA | |||||||||||||||||
| Species | Mycobacterium tuberculosis | |||||||||||||||||
| Uniprot ID | TYSY_MYCTU | |||||||||||||||||
| Sequence | MTPYEDLLRFVLETGTPKSDRTGTGTRSLFGQQMRYDLSAGFPLLTTKKVHFKSVAYELL WFLRGDSNIGWLHEHGVTIWDEWASDTGELGPIYGVQWRSWPAPSGEHIDQISAALDLLR TDPDSRRIIVSAWNVGEIERMALPPCHAFFQFYVADGRLSCQLYQRSADLFLGVPFNIAS YALLTHMMAAQAGLSVGEFIWTGGDCHIYDNHVEQVRLQLSREPRPYPKLLLADRDSIFE YTYEDIVVKNYDPHPAIKAPVAV [Mycobacterium tuberculosis] |
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| Drug Resistance Mutation and Corresponding Drugs | ||||||||||||||||||
| Mutation Info | Missense: R222G | |||||||||||||||||
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| Mutation Info | Missense: T202A | |||||||||||||||||
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| Reference | ||||||||||||||||||
| REF 1 | The folate pathway is a target for resistance to the drug para-aminosalicylic acid (PAS) in mycobacteria. Mol Microbiol. 2004 Jul;53(1):275-82. | |||||||||||||||||
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