| Target General Information |
|---|
| Target ID |
T79068 |
| Target Name |
Bacterial Enoyl-[acyl-carrier-protein] reductase [NADH] (Inha) |
Target Info
|
| Gene Name |
inhA |
| Species |
Mycobacterium tuberculosis |
| Uniprot ID |
INHA_MYCTU |
| Sequence |
MTGLLDGKRILVSGIITDSSIAFHIARVAQEQGAQLVLTGFDRLRLIQRITDRLPAKAPL
LELDVQNEEHLASLAGRVTEAIGAGNKLDGVVHSIGFMPQTGMGINPFFDAPYADVSKGI
HISAYSYASMAKALLPIMNPGGSIVGMDFDPSRAMPAYNWMTVAKSALESVNRFVAREAG
KYGVRSNLVAAGPIRTLAMSAIVGGALGEEAGAQIQLLEEGWDQRAPIGWNMKDATPVAK
TVCALLSDWLPATTGDIIYADGGAHTQLL [Mycobacterium tuberculosis] |
| Drug Resistance Mutation and Corresponding Drugs |
|---|
| Mutation Info |
Missense: E217D |
| Drugs |
| Drug Name |
Isoniazid |
Drug Info |
[1]
|
| Targeted Disease |
Tuberculosis |
| Mutation Prevalence |
1 out of 28 isolates |
|
| Mutation Info |
Missense: I16T |
| Drugs |
| Drug Name |
Isoniazid |
Drug Info |
[2],
[3]
|
| Targeted Disease |
Tuberculosis |
|
| Mutation Info |
Missense: I194T |
| Drugs |
| Drug Name |
Isoniazid |
Drug Info |
[4],
[3]
|
| Targeted Disease |
Tuberculosis |
| Mutation Prevalence |
52 out of 102 isolates |
|
| Mutation Info |
Missense: I21T |
| Drugs |
| Drug Name |
Isoniazid |
Drug Info |
[5],
[3]
|
| Targeted Disease |
Tuberculosis |
|
| Mutation Info |
Missense: I21V |
| Drugs |
| Drug Name |
Isoniazid |
Drug Info |
[5],
[3]
|
| Targeted Disease |
Tuberculosis |
|
| Mutation Info |
Missense: I47T |
| Drugs |
| Drug Name |
Isoniazid |
Drug Info |
[2],
[3]
|
| Targeted Disease |
Tuberculosis |
|
| Mutation Info |
Missense: I95P |
| Drugs |
| Drug Name |
Isoniazid |
Drug Info |
[6],
[3]
|
| Targeted Disease |
Tuberculosis |
| Mutation Prevalence |
7 out of 14 isolates |
|
| Drug Name |
Ethionamide |
Drug Info |
[6]
|
| Targeted Disease |
Tuberculosis |
| Mutation Prevalence |
7 out of 14 isolates |
|
| Mutation Info |
Missense: I95T |
| Drugs |
| Drug Name |
Isoniazid |
Drug Info |
[7]
|
| Targeted Disease |
Tuberculosis |
|
| Mutation Info |
Missense: K8N |
| Drugs |
| Drug Name |
Isoniazid |
Drug Info |
[8]
|
| Targeted Disease |
Tuberculosis |
|
| Mutation Info |
Missense: R202G |
| Drugs |
| Drug Name |
Isoniazid |
Drug Info |
[1]
|
| Targeted Disease |
Tuberculosis |
| Mutation Prevalence |
1 out of 28 isolates |
|
| Mutation Info |
Missense: S94A |
| Drugs |
| Drug Name |
Isoniazid |
Drug Info |
[9],
[3]
|
| Targeted Disease |
Tuberculosis |
|
| Drug Name |
Ethionamide |
Drug Info |
[9]
|
| Targeted Disease |
Tuberculosis |
|
| Mutation Info |
Missense: S94L |
| Drugs |
| Drug Name |
Isoniazid |
Drug Info |
[10]
|
| Targeted Disease |
Tuberculosis |
|
| Mutation Info |
Missense: V78A |
| Drugs |
| Drug Name |
Isoniazid |
Drug Info |
[2],
[3]
|
| Targeted Disease |
Tuberculosis |
|
| Reference |
|---|
| REF 1 | Performance assessment of the GenoType MTBDRplus test and DNA sequencing in detection of multidrug-resistant Mycobacterium tuberculosis. J Clin Microbiol. 2009 Aug;47(8):2520-4. doi: 10.1128/JCM.02499-08. Epub 2009 Jun 3. |
|---|
| REF 2 | Mechanisms of isoniazid resistance in Mycobacterium tuberculosis: enzymatic characterization of enoyl reductase mutants identified in isoniazid-resistant clinical isolates. J Infect Dis. 1998 Sep;178(3):769-75. |
|---|
| REF 3 | CARD 2017: expansion and model-centric curation of the comprehensive antibiotic resistance database. Nucleic Acids Res. 2017 Jan 4;45(D1):D566-D573. doi: 10.1093/nar/gkw1004. Epub 2016 Oct 26. |
|---|
| REF 4 | Molecular characterization of isoniazid resistance in Mycobacterium tuberculosis: identification of a novel mutation in inhA. Antimicrob Agents Chemother. 2006 Mar;50(3):1075-8. |
|---|
| REF 5 | ethA, inhA, and katG loci of ethionamide-resistant clinical Mycobacterium tuberculosis isolates. Antimicrob Agents Chemother. 2003 Dec;47(12):3799-805. |
|---|
| REF 6 | New isoniazid/ethionamide resistance gene mutation and screening for multidrug-resistant Mycobacterium tuberculosis strains. Lancet. 1995 Aug 19;346(8973):502-3. |
|---|
| REF 7 | Molecular genetic basis of antimicrobial agent resistance in Mycobacterium tuberculosis: 1998 update. Tuber Lung Dis. 1998;79(1):3-29. |
|---|
| REF 8 | http://www.ncbi.nlm.nih.gov/pubmed/2007582629 |
|---|
| REF 9 | Exclusive mutations related to isoniazid and ethionamide resistance among Mycobacterium tuberculosis isolates from Korea. Int J Tuberc Lung Dis. 2000 May;4(5):441-7. |
|---|
| REF 10 | Transfer of a point mutation in Mycobacterium tuberculosis inhA resolves the target of isoniazid. Nat Med. 2006 Sep;12(9):1027-9. Epub 2006 Aug 13. |
|---|
