Target Information
Target General Infomation | |||||
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Target ID |
T90648
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Former ID |
TTDR01373
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Target Name |
mRNA of B-Raf
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Gene Name |
BRAF
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Synonyms |
Proto-oncogene B-Raf (mRNA); Serine/threonine-protein kinase B-raf (mRNA); p94 (mRNA); v-Raf murine sarcoma viral oncogene homolog B1 (mRNA); BRAF
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Target Type |
Clinical Trial
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Disease | Cancer [ICD9: 140-229; ICD10: C00-C96] | ||||
Parkinson's disease [ICD9: 332; ICD10: G20] | |||||
Solid tumours [ICD9: 140-199, 210-229; ICD10: C00-D48] | |||||
BioChemical Class |
Kinase
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Target Validation |
T90648
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UniProt ID | |||||
EC Number |
EC 2.7.11.1
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Sequence |
MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEH
IEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTV TSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDS LKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRK TFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPI PQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQR DRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSP GPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDV AVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHH LHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATV KSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNIN NRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARS LPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH |
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Drugs and Mode of Action | |||||
Inhibitor | 2-(Benzylamino)-6-(3-acetamidophenyl)pyrazine | Drug Info | [527954] | ||
2-(Phenylamino)-6-(3-acetamidophenyl)pyrazine | Drug Info | [527954] | |||
BIIB-024 | Drug Info | [543525] | |||
compound 2 | Drug Info | [533265] | |||
L-779450 | Drug Info | [527836] | |||
PLX-4720 | Drug Info | [531679] | |||
PLX-ORI3 | Drug Info | [543525] | |||
Pyrazolo[1,5-a]pyrimidine-3-carboxylate | Drug Info | [530074] | |||
RG7304 | Drug Info | [551608] | |||
ZM-336372 | Drug Info | [529039] | |||
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM) | |||||
TEP | EXP Info | ||||
Pathways | |||||
KEGG Pathway | MAPK signaling pathway | ||||
ErbB signaling pathway | |||||
Rap1 signaling pathway | |||||
cAMP signaling pathway | |||||
Chemokine signaling pathway | |||||
FoxO signaling pathway | |||||
mTOR signaling pathway | |||||
Vascular smooth muscle contraction | |||||
Focal adhesion | |||||
Natural killer cell mediated cytotoxicity | |||||
Long-term potentiation | |||||
Neurotrophin signaling pathway | |||||
Serotonergic synapse | |||||
Long-term depression | |||||
Regulation of actin cytoskeleton | |||||
Insulin signaling pathway | |||||
Progesterone-mediated oocyte maturation | |||||
Alcoholism | |||||
Hepatitis C | |||||
Pathways in cancer | |||||
Proteoglycans in cancer | |||||
Colorectal cancer | |||||
Renal cell carcinoma | |||||
Pancreatic cancer | |||||
Endometrial cancer | |||||
Glioma | |||||
Prostate cancer | |||||
Thyroid cancer | |||||
Melanoma | |||||
Bladder cancer | |||||
Chronic myeloid leukemia | |||||
Acute myeloid leukemia | |||||
Non-small cell lung cancer | |||||
NetPath Pathway | IL-7 Signaling Pathway | ||||
PANTHER Pathway | Angiogenesis | ||||
Integrin signalling pathway | |||||
Interleukin signaling pathway | |||||
PDGF signaling pathway | |||||
T cell activation | |||||
VEGF signaling pathway | |||||
Ras Pathway | |||||
CCKR signaling map ST | |||||
Pathway Interaction Database | CDC42 signaling events | ||||
mTOR signaling pathway | |||||
Ras signaling in the CD4+ TCR pathway | |||||
ErbB1 downstream signaling | |||||
PDGFR-beta signaling pathway | |||||
Signaling events mediated by VEGFR1 and VEGFR2 | |||||
Trk receptor signaling mediated by the MAPK pathway | |||||
PathWhiz Pathway | Intracellular Signalling Through Adenosine Receptor A2a and Adenosine | ||||
Intracellular Signalling Through Adenosine Receptor A2b and Adenosine | |||||
Reactome | Spry regulation of FGF signaling | ||||
Frs2-mediated activation | |||||
ARMS-mediated activation | |||||
CREB phosphorylation through the activation of Ras | |||||
RAF activation | |||||
MAP2K and MAPK activation | |||||
Negative feedback regulation of MAPK pathway | |||||
Negative regulation of MAPK pathway | |||||
WikiPathways | Serotonin Receptor 4/6/7 and NR3C Signaling | ||||
Serotonin HTR1 Group and FOS Pathway | |||||
Senescence and Autophagy in Cancer | |||||
Regulation of Actin Cytoskeleton | |||||
EGF/EGFR Signaling Pathway | |||||
MAPK Cascade | |||||
MAPK Signaling Pathway | |||||
Bladder Cancer | |||||
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | |||||
Polycystic Kidney Disease Pathway | |||||
Corticotropin-releasing hormone | |||||
B Cell Receptor Signaling Pathway | |||||
Signaling Pathways in Glioblastoma | |||||
Integrated Breast Cancer Pathway | |||||
Signaling by FGFR | |||||
NGF signalling via TRKA from the plasma membrane | |||||
Integrin-mediated Cell Adhesion | |||||
References | |||||
Ref 527836 | Bioorg Med Chem Lett. 2006 Jan 15;16(2):378-81. Epub 2005 Nov 2.The identification of potent and selective imidazole-based inhibitors of B-Raf kinase. | ||||
Ref 527954 | J Med Chem. 2006 Jan 12;49(1):407-16.Novel inhibitors of B-RAF based on a disubstituted pyrazine scaffold. Generation of a nanomolar lead. | ||||
Ref 529039 | Biochem J. 2007 Dec 15;408(3):297-315.The selectivity of protein kinase inhibitors: a further update. | ||||
Ref 530074 | Bioorg Med Chem Lett. 2009 May 15;19(10):2735-8. Epub 2009 Mar 28.Identification of pyrazolo[1,5-a]pyrimidine-3-carboxylates as B-Raf kinase inhibitors. | ||||
Ref 531679 | Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol. 2011 Oct 30;29(11):1046-51. | ||||
Ref 533265 | Photoactivatable Prodrugs of Antimelanoma Agent Vemurafenib. ACS Chem Biol. 2015 Sep 18;10(9):2099-107. | ||||
Ref 543525 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1943). |
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