Target Information
Target General Infomation | |||||
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Target ID |
T89054
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Former ID |
TTDR00113
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Target Name |
Adenylosuccinate synthetase
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Gene Name |
Adss
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Synonyms |
AMPSase; AdSS; Adenylosuccinate synthase; IMP--aspartate ligase; Adss
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Target Type |
Clinical Trial
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Function |
Plays an important role in the salvage pathway for purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity).
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BioChemical Class |
Carbon-nitrogen ligase
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UniProt ID | |||||
EC Number |
EC 6.3.4.4
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Sequence |
MNIFDHQIKNVDKGNVVAILGAQWGDEGKGKIIDMLSEYSDITCRFNGGANAGHTISVND
KKYALHLLPCGVLYDNNISVLGNGMVIHVKSLMEEIESVGGKLLDRLYLSNKAHILFDIH QIIDSIQETKKLKEGKQIGTTKRGIGPCYSTKASRIGIRLGTLKNFENFKNMYSKLIDHL MDLYNITEYDKEKELNLFYNYHIKLRDRIVDVISFMNTNLENNKKVLIEGANAAMLDIDF GTYPYVTSSCTTVGGVFSGLGIHHKKLNLVVGVVKSYLTRVGCGPFLTELNNDVGQYLRE KGHEYGTTTKRPRRCGWLDIPMLLYVKCINSIDMINLTKLDVLSGLEEILLCVNFKNKKT GELLEKGCYPVEEEISEEYEPVYEKFSGWKEDISTCNEFDELPENAKKYILAIEKYLKTP IVWIGVGPNRKNMIVKKNFNLN |
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Drugs and Mode of Action | |||||
Inhibitor | (C8-R)-Hydantocidin 5'-Phosphate | Drug Info | [551393] | ||
(C8-S)-Hydantocidin 5'-Phosphate | Drug Info | [551393] | |||
(Carboxyhydroxyamino)Ethanoic Acid | Drug Info | [551393] | |||
6-O-Phosphoryl Inosine Monophosphate | Drug Info | [551393] | |||
Alanosine | Drug Info | [536240] | |||
Beta-Mercaptoethanol | Drug Info | [551393] | |||
Diphosphate | Drug Info | [551393] | |||
Guanosine-5'-Diphosphate | Drug Info | [551393] | |||
Hadacidin | Drug Info | [537908] | |||
Hydantocidin-5'-Monophosphate | Drug Info | [551393] | |||
Hydantocidin-5'-Phosphate | Drug Info | [551393] | |||
Inosinic Acid | Drug Info | [551393] | |||
References | |||||
Ref 536240 | Lack of methylthioadenosine phosphorylase expression in mantle cell lymphoma is associated with shorter survival: implications for a potential targeted therapy. Clin Cancer Res. 2006 Jun 15;12(12):3754-61. |
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