Target Information
Target General Infomation | |||||
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Target ID |
T47888
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Former ID |
TTDI02522
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Target Name |
Sphingosine-1-phosphate receptor-2
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Gene Name |
S1PR2
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Synonyms |
Endothelial differentiation G-protein coupled receptor 5; S1P receptor 2; S1P receptor Edg-5; S1P2; Sphingosine 1-phosphate receptor Edg-5; S1PR2
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Target Type |
Research
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Disease | Hypertension [ICD9: 401; ICD10: I10-I16] | ||||
Function |
Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis.
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BioChemical Class |
GPCR rhodopsin
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UniProt ID | |||||
Sequence |
MGSLYSEYLNPNKVQEHYNYTKETLETQETTSRQVASAFIVILCCAIVVENLLVLIAVAR
NSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGSVTLRLTPVQWFAREGSAFITLSASV FSLLAIAIERHVAIAKVKLYGSDKSCRMLLLIGASWLISLVLGGLPILGWNCLGHLEACS TVLPLYAKHYVLCVVTIFSIILLAIVALYVRIYCVVRSSHADMAAPQTLALLKTVTIVLG VFIVCWLPAFSILLLDYACPVHSCPILYKAHYFFAVSTLNSLLNPVIYTWRSRDLRREVL RPLQCWRPGVGVQGRRRGGTPGHHLLPLRSSSSLERGMHMPTSPTFLEGNTVV |
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Pathways | |||||
KEGG Pathway | Sphingolipid signaling pathway | ||||
Neuroactive ligand-receptor interaction | |||||
Pathway Interaction Database | S1P3 pathway | ||||
Sphingosine 1-phosphate (S1P) pathway | |||||
S1P2 pathway | |||||
Reactome | G alpha (i) signalling events | ||||
Lysosphingolipid and LPA receptors | |||||
WikiPathways | Signal Transduction of S1P Receptor | ||||
Small Ligand GPCRs | |||||
GPCR ligand binding | |||||
GPCR downstream signaling | |||||
References | |||||
Ref 526465 | Enhancement of sphingosine 1-phosphate-induced migration of vascular endothelial cells and smooth muscle cells by an EDG-5 antagonist. Biochem Biophys Res Commun. 2002 Dec 6;299(3):483-7. |
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