Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T30727
|
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| Former ID |
TTDR00455
|
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| Target Name |
Caspase-11
|
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| Gene Name |
Casp4
|
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| Synonyms |
ICH-3 protease; Casp4
|
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| Target Type |
Research
|
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| Function |
Involved in ER-stress induced apoptosis. Cleaves caspase-1 (By similarity). Involved in the activation cascade of caspases responsible for apoptosis execution. Promotes IL-1 beta processing by ICE, so may also have a role in inflammatory responses.
|
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| BioChemical Class |
Peptidase
|
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| Target Validation |
T30727
|
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| UniProt ID | |||||
| EC Number |
EC 3.4.22.-
|
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| Sequence |
MAENKHPDKPLKVLEQLGKEVLTEYLEKLVQSNVLKLKEEDKQKFNNAERSDKRWVFVDA
MKKKHSKVGEMLLQTFFSVDPGSHHGEANLEMEEPEESLNTLKLCSPEEFTRLCREKTQE IYPIKEANGRTRKALIICNTEFKHLSLRYGANFDIIGMKGLLEDLGYDVVVKEELTAEGM ESEMKDFAALSEHQTSDSTFLVLMSHGTLHGICGTMHSEKTPDVLQYDTIYQIFNNCHCP GLRDKPKVIIVQACRGGNSGEMWIRESSKPQLCRGVDLPRNMEADAVKLSHVEKDFIAFY STTPHHLSYRDKTGGSYFITRLISCFRKHACSCHLFDIFLKVQQSFEKASIHSQMPTIDR ATLTRYFYLFPGN |
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| References | |||||
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