Target Information

Target General Infomation
Target ID
T54472
Former ID
TTDR00299
Target Name
Cyclin-dependent protein kinase PfPK5
Gene Name
CRK2
Synonyms
Cell division control protein 2 homolog; CRK2
Target Type
Research
Function
Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. Component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II (By similarity).
BioChemical Class
Kinase
UniProt ID
Q07785
EC Number
EC 2.7.1.-
Sequence
MEKYHGLEKIGEGTYGVVYKAQNNYGETFALKKIRLEKEDEGIPSTTIREISILKELKHS
NIVKLYDVIHTKKRLVLVFEHLDQDLKKLLDVCEGGLESVTAKSFLLQLLNGIAYCHDRR
VLHRDLKPQNLLINREGELKIADFGLARAFGIPVRKYTHEVVTLWYRAPDVLMGSKKYST
TIDIWSVGCIFAEMVNGTPLFPGVSEADQLMRIFRILGTPNSKNWPNVTELPKYDPNFTV
YEPLPWESFLKGLDESGIDLLSKMLKLDPNQRITAKQALEHAYFKENN
Inhibitor Aminopurvalanol Drug Info [535751]
Indirubin-5-Sulphonate Drug Info [551393]
References
Ref 535751M-phase regulation of the recruitment of mRNAs onto polysomes using the CDK1/cyclin B inhibitor aminopurvalanol. Biochem Biophys Res Commun. 2003 Jul 11;306(4):880-6.
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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