Target Information
Target General Infomation | |||||
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Target ID |
T68834
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Former ID |
TTDI03427
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Target Name |
OXE receptor
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Gene Name |
OXER1
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Synonyms |
OXER1
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Target Type |
Research
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UniProt ID | |||||
Sequence |
MLCHRGGQLIVPIIPLCPEHSCRGRRLQNLLSGPWPKQPMELHNLSSPSPSLSSSVLPPS
FSPSPSSAPSAFTTVGGSSGGPCHPTSSSLVSAFLAPILALEFVLGLVGNSLALFIFCIH TRPWTSNTVFLVSLVAADFLLISNLPLRVDYYLLHETWRFGAAACKVNLFMLSTNRTASV VFLTAIALNRYLKVVQPHHVLSRASVGAAARVAGGLWVGILLLNGHLLLSTFSGPSCLSY RVGTKPSASLRWHQALYLLEFFLPLALILFAIVSIGLTIRNRGLGGQAGPQRAMRVLAMV VAVYTICFLPSIIFGMASMVAFWLSACRSLDLCTQLFHGSLAFTYLNSVLDPVLYCFSSP NFLHQSRALLGLTRGRQGPVSDESSYQPSRQWRYREASRKAEAIGKLKVQGEVSLEKEGS SQG |
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Antagonist | 5-(6-chloro-2-hexyl-1H-indol-1-yl)-5-oxo-valeric acid | Drug Info | [532305] | ||
5-oxo-12-HETE | Drug Info | [534822] | |||
Agonist | 5-oxo-15-HETE | Drug Info | [534106] | ||
5-oxo-20-HETE | Drug Info | [534106] | |||
5-oxo-C20:3 | Drug Info | [529330] | |||
5-oxo-ETE | Drug Info | [526748] | |||
5-oxo-ODE | Drug Info | [529321] | |||
5S-HETE | Drug Info | [527658] | |||
5S-HPETE | Drug Info | [527658] | |||
[3H]5-oxo-ETE | Drug Info | [534758] | |||
Modulator (allosteric modulator) | Gue1654 | Drug Info | [531925] | ||
References | |||||
Ref 526748 | Metabolism of 5(S)-hydroxy-6,8,11,14-eicosatetraenoic acid and other 5(S)-hydroxyeicosanoids by a specific dehydrogenase in human polymorphonuclear leukocytes. J Biol Chem. 1992 Sep 25;267(27):19233-41. | ||||
Ref 527658 | TG1019/OXE, a Galpha(i/o)-protein-coupled receptor, mediates 5-oxo-eicosatetraenoic acid-induced chemotaxis. Biochem Biophys Res Commun. 2005 Sep 9;334(4):987-95. | ||||
Ref 529321 | Human neutrophils convert the sebum-derived polyunsaturated fatty acid Sebaleic acid to a potent granulocyte chemoattractant. J Biol Chem. 2008 Apr 25;283(17):11234-43. | ||||
Ref 529330 | Structural requirements for activation of the 5-oxo-6E,8Z, 11Z,14Z-eicosatetraenoic acid (5-oxo-ETE) receptor: identification of a mead acid metabolite with potent agonist activity. J Pharmacol Exp Ther. 2008 May;325(2):698-707. | ||||
Ref 531925 | A biased ligand for OXE-R uncouples Galpha and Gbetagamma signaling within a heterotrimer. Nat Chem Biol. 2012 Jul;8(7):631-8. | ||||
Ref 534106 | Metabolism and biologic effects of 5-oxoeicosanoids on human neutrophils. J Immunol. 1996 Jan 1;156(1):336-42. |
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