Target General Infomation
Target ID
T37271
Former ID
TTDR00415
Target Name
Lactosylceramide alpha-2,3-sialyltransferase
Gene Name
ST3GAL5
Synonyms
CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase; Ganglioside GM3 synthase; ST3Gal V; Sialyltransferase 9; UNQ2510/PRO5998; ST3GAL5
Target Type
Research
Function
Catalyzes the formation of ganglioside GM3 (alpha-N- acetylneuraminyl-2,3-beta-D-galactosyl-1, 4-beta-D- glucosylceramide).
BioChemical Class
Transferases of glycosyl groups
UniProt ID
EC Number
EC 2.4.99.9
Sequence
MRTKAAGCAERRPLQPRTEAAAAPAGRAMPSEYTYVKLRSDCSRPSLQWYTRAQSKMRRP
SLLLKDILKCTLLVFGVWILYILKLNYTTEECDMKKMHYVDPDHVKRAQKYAQQVLQKEC
RPKFAKTSMALLFEHRYSVDLLPFVQKAPKDSEAESKYDPPFGFRKFSSKVQTLLELLPE
HDLPEHLKAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTI
RMTYPEGAPLSDLEYYSNDLFVAVLFKSVDFNWLQAMVKKETLPFWVRLFFWKQVAEKIP
LQPKHFRILNPVIIKETAFDILQYSEPQSRFWGRDKNVPTIGVIAVVLATHLCDEVSLAG
FGYDLNQPRTPLHYFDSQCMAAMNFQTMHNVTTETKFLLKLVKEGVVKDLSGGIDREF
Inhibitor 5'-deoxy-5'-[(3-hydrazinopropyl)methylamino]adenosine Drug Info [535793]
Pathways
KEGG Pathway Glycosphingolipid biosynthesis - ganglio series
Metabolic pathways
Reactome Sialic acid metabolism
WikiPathways Ganglio Sphingolipid Metabolism
References
Ref 535793S-adenosylmethionine decarboxylase as an enzyme target for therapy. Pharmacol Ther. 1992 Dec;56(3):359-77.

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