Drug Information

Drug General Information
Drug ID
D02WRU
Former ID
DIB020716
Drug Name
PHTPP
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540399]
Structure
Download
2D MOL
Formula
C20H11F6N3O
InChI
InChI=1S/C20H11F6N3O/c21-19(22,23)14-10-15(20(24,25)26)29-18(27-14)16(11-6-8-13(30)9-7-11)17(28-29)12-4-2-1-3-5-12/h1-10,30H
InChIKey
AEZPAUSGTAHLOQ-UHFFFAOYSA-N
PubChem Compound ID
11201035
PubChem Substance ID
16282862, 23387561, 42280702, 46519473, 47213229, 50112959, 79411437, 85788220, 103458915, 135653858, 135698684, 135713163, 136900538, 162023504, 163125959, 178100457, 204361752, 240495554, 241376060, 247521134, 249617650, 252156694, 252451016
Target and Pathway
Target(s) Estrogen receptor beta Target Info Antagonist [528623]
KEGG Pathway Estrogen signaling pathway
Prolactin signaling pathway
Pathway Interaction Database Plasma membrane estrogen receptor signaling
Validated nuclear estrogen receptor beta network
Validated nuclear estrogen receptor alpha network
Reactome Nuclear Receptor transcription pathway
WikiPathways SIDS Susceptibility Pathways
Ovarian Infertility Genes
Integrated Pancreatic Cancer Pathway
Nuclear Receptors
References
Ref 540399(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3461).
Ref 528623Structure-guided optimization of estrogen receptor binding affinity and antagonist potency of pyrazolopyrimidines with basic side chains. J Med Chem. 2007 Jan 25;50(2):399-403.

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