| Drug General Information |
| Drug ID |
D0IJ7H
|
| Former ID |
DNC002676
|
| Drug Name |
3-Hydroxy-3-Methyl-Glutaric Acid
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C6H10O5
|
| Canonical SMILES |
CC(CC(=O)O)(CC(=O)O)O
|
| InChI |
1S/C6H10O5/c1-6(11,2-4(7)8)3-5(9)10/h11H,2-3H2,1H3,(H,7,8)(H,9,10)
|
| InChIKey |
NPOAOTPXWNWTSH-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
6518, 465638, 837449, 837453, 3138613, 4360728, 7888751, 8145751, 8151224, 12015709, 15147019, 24895642, 29220866, 46508063, 47193667, 47206661, 48334702, 48334703, 49973038, 50113539, 57320970, 57654253, 74614918, 85165135, 87570836, 88531321, 92298537, 103232312, 104047199, 104298356, 104829164, 118693189, 121362113, 125482710, 126523199, 126558056, 128736160, 134342184, 134975893, 135366238, 137006331, 139145840, 144027053, 144076405, 160798467, 160967404, 162265616, 163086679, 164188133, 164810982
|
| Target and Pathway |
| Target(s) |
3-hydroxy-3-methylglutaryl-coenzyme A reductase |
Target Info |
Inhibitor |
[1]
|
|---|
|
BioCyc Pathway
|
Superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)
|
|
Superpathway of cholesterol biosynthesis
|
|
Mevalonate pathway
|
|
KEGG Pathway
|
Terpenoid backbone biosynthesis
|
|
Metabolic pathways
|
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Biosynthesis of antibiotics
|
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AMPK signaling pathway
|
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Bile secretion
|
|
NetPath Pathway
|
IL5 Signaling Pathway
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TGF_beta_Receptor Signaling Pathway
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TSH Signaling Pathway
|
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PANTHER Pathway
|
Cholesterol biosynthesis
|
|
PathWhiz Pathway
|
Steroid Biosynthesis
|
|
WikiPathways
|
Statin Pathway
|
|
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
|
|
Activation of Gene Expression by SREBP (SREBF)
|
|
SREBF and miR33 in cholesterol and lipid homeostasis
|
|
Integrated Breast Cancer Pathway
|
|
SREBP signalling
|
|
Cholesterol Biosynthesis
|
| References |
| REF 1 | How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. |
|---|
