Drug Information

Drug General Information
Drug ID
D0Z4XW
Former ID
DAP001449
Drug Name
Topetecan
Drug Type
Small molecular drug
Indication Small-cell lung cancer [ICD9: 162.9; ICD10:C33-C34] Approved [538552]
Company
GSK
Structure
Download
2D MOL

3D MOL
Formula
C23H24ClN3O5
Canonical SMILES
CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C=CC(=C(C5=C4)C<br />N(C)C)O)O.Cl
InChI
1S/C23H23N3O5.ClH/c1-4-23(30)16-8-18-20-12(9-26(18)21(28)15(16)11-31-22(23)29)7-13-14(10-25(2)3)19(27)6-5-17(13)24-20;/h5-8,27,30H,4,9-11H2,1-3H3;1H/t23-;/m0./s1
InChIKey
DGHHQBMTXTWTJV-BQAIUKQQSA-N
PubChem Compound ID
60699
PubChem Substance ID
580652, 4254372, 7849229, 8187012, 12014351, 14808962, 14858018, 26612947, 26652314, 26719851, 26749084, 26749085, 43118055, 46386667, 49681835, 50064238, 50107520, 57314069, 77238590, 81043930, 91011865, 92124726, 92711334, 99437042, 103592348, 104133510, 104321413, 117451252, 118844639, 124635315, 124757103, 125163907, 126630966, 126657419, 126665399, 134338648, 135017834, 136340285, 136378525, 144075973, 144205031, 152039834, 160848176, 162037509, 162176905, 164194986, 164814890, 170465137, 172080300, 174474422
Target and Pathway
Target(s) DNA topoisomerase I Target Info Inhibitor [550963]
WikiPathways Integrated Pancreatic Cancer Pathway
References
Ref 538552FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 020671.
Ref 550963Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).

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