Drug Information

Drug General Information
Drug ID
D04FFY
Former ID
DCL000046
Drug Name
AMG-8563
Drug Type
Small molecular drug
Indication Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89] Investigative [532079]
Therapeutic Class
Analgesics
Company
Amgen
Structure
Download
2D MOL

3D MOL
Formula
C24H25F3N2O2
Canonical SMILES
C1CCN(CC1)C2=C(C=CC(=C2)C(F)(F)F)C=CC(=O)NC3=CC=CC4=C3C<br />C(C4)O
InChI
1S/C24H25F3N2O2/c25-24(26,27)18-9-7-16(22(14-18)29-11-2-1-3-12-29)8-10-23(31)28-21-6-4-5-17-13-19(30)15-20(17)21/h4-10,14,19,30H,1-3,11-13,15H2,(H,28,31)/b10-8+/t19-/m0/s1
InChIKey
HAZYXDWNLMGLIS-RQMBKDMJSA-N
PubChem Compound ID
24863103
PubChem Substance ID
50095079, 119756299, 134338752, 240391012
Target and Pathway
Target(s) Vanilloid receptor 1 Target Info Blocker [537396]
KEGG Pathway Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
NetPath Pathway IL2 Signaling Pathway
Pathway Interaction Database Trk receptor signaling mediated by the MAPK pathway
Trk receptor signaling mediated by PI3K and PLC-gamma
Reactome TRP channels
References
Ref 532079Altered pharmacology of native rodent spinal cord TRPV1 after phosphorylation. Br J Pharmacol. 2013 Feb;168(4):1015-29.
Ref 537396Analgesic potential of TRPV1 antagonists. Biochem Pharmacol. 2009 Aug 1;78(3):211-6. Epub 2009 Mar 5.

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