Drug General Information
Drug ID	D0P0WT
Former ID	DNC004100
Drug Name	5,7-Dimethoxy-3-pyridin-4-yl-quinoline
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[533872]
Structure		Download 2D MOL 3D MOL
Formula	C16H14N2O2
Canonical SMILES	COC1=CC2=NC=C(C=C2C(=C1)OC)C3=CC=NC=C3
InChI	1S/C16H14N2O2/c1-19-13-8-15-14(16(9-13)20-2)7-12(10-18-15)11-3-5-17-6-4-11/h3-10H,1-2H3
InChIKey	HBXDLZBPKJEWHZ-UHFFFAOYSA-N
PubChem Compound ID	3139
Target and Pathway
Target(s)	Alpha platelet-derived growth factor receptor	Target Info	Inhibitor	[533872]
	Beta platelet-derived growth factor receptor	Target Info	Inhibitor	[533872]
KEGG Pathway	MAPK signaling pathway
	Ras signaling pathway
	Rap1 signaling pathway
	Calcium signaling pathway
	Cytokine-cytokine receptor interaction
	Endocytosis
	PI3K-Akt signaling pathway
	Focal adhesion
	Gap junction
	Regulation of actin cytoskeleton
	HTLV-I infection
	Pathways in cancer
	MicroRNAs in cancer
	Glioma
	Prostate cancer
	Melanoma
	Central carbon metabolism in cancer
	Choline metabolism in cancerhsa04010:MAPK signaling pathway
	Choline metabolism in cancer
NetPath Pathway	TGF_beta_Receptor Signaling Pathway
PANTHER Pathway	Angiogenesis
	PDGF signaling pathwayP00005:Angiogenesis
	PDGF signaling pathway
Pathway Interaction Database	ATF-2 transcription factor network
	PDGFR-alpha signaling pathway
	PDGF receptor signaling networkptp1bpathway:Signaling events mediated by PTP1B
	Beta3 integrin cell surface interactions
	S1P3 pathway
	Nectin adhesion pathway
	Signaling events mediated by TCPTP
	SHP2 signaling
	S1P1 pathway
	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
	PDGFR-beta signaling pathway
	Validated targets of C-MYC transcriptional repression
	PDGF receptor signaling network
Reactome	PIP3 activates AKT signaling
	Constitutive Signaling by Aberrant PI3K in Cancer
	RAF/MAP kinase cascadeR-HSA-1257604:PIP3 activates AKT signaling
	RAF/MAP kinase cascade
WikiPathways	Regulation of Actin Cytoskeleton
	Osteoblast Signaling
	Focal Adhesion
	Hair Follicle Development: Organogenesis (Part 2 of 3)
	PIP3 activates AKT signaling
	Cardiac Progenitor Differentiation
	Integrated Pancreatic Cancer Pathway
	Allograft Rejection
	Signaling Pathways in Glioblastoma
	Signaling by PDGF
	AngiogenesisWP51:Regulation of Actin Cytoskeleton
	MAPK Signaling Pathway
	PDGF Pathway
References
Ref 533872	J Med Chem. 1994 Aug 19;37(17):2627-9.5,7-Dimethoxy-3-(4-pyridinyl)quinoline is a potent and selective inhibitor of human vascular beta-type platelet-derived growth factor receptor tyrosine kinase.
Ref 533872	J Med Chem. 1994 Aug 19;37(17):2627-9.5,7-Dimethoxy-3-(4-pyridinyl)quinoline is a potent and selective inhibitor of human vascular beta-type platelet-derived growth factor receptor tyrosine kinase.

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