Drug General Information
Drug ID	D0L4WN
Former ID	DNC010365
Drug Name	1,4-diaminoanthracene-9,10-dione
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[530650]
Structure		Download 2D MOL 3D MOL
Formula	C14H10N2O2
Canonical SMILES	C1=CC=C2C(=C1)C(=O)C3=C(C=CC(=C3C2=O)N)N
InChI	1S/C14H10N2O2/c15-9-5-6-10(16)12-11(9)13(17)7-3-1-2-4-8(7)14(12)18/h1-6H,15-16H2
InChIKey	FBMQNRKSAWNXBT-UHFFFAOYSA-N
PubChem Compound ID	31420
Target and Pathway
Target(s)	Adenosine A2a receptor	Target Info	Inhibitor	[530650]
KEGG Pathway	Rap1 signaling pathway
	Calcium signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Vascular smooth muscle contraction
	Parkinson's disease
	Alcoholism
Pathway Interaction Database	HIF-2-alpha transcription factor network
PathWhiz Pathway	Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Reactome	NGF-independant TRKA activation
	Adenosine P1 receptors
	G alpha (s) signalling events
	Surfactant metabolism
WikiPathways	Nucleotide GPCRs
	Monoamine Transport
	GPCRs, Class A Rhodopsin-like
	NGF signalling via TRKA from the plasma membrane
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, Other
References
Ref 530650	J Med Chem. 2010 Feb 25;53(4):1799-809.Structure-based discovery of novel chemotypes for adenosine A(2A) receptor antagonists.
Ref 530650	J Med Chem. 2010 Feb 25;53(4):1799-809.Structure-based discovery of novel chemotypes for adenosine A(2A) receptor antagonists.

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