Drug Information

Drug General Information
Drug ID
D0GR9O
Former ID
DNC005421
Drug Name
AGN-34
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527690]
Structure
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2D MOL

3D MOL
Formula
C27H40O3
Canonical SMILES
CCCCCCOC1=C(C=C(C=C1C(=CC=CC(=CC(=O)O)C)C)C(C)C)C(C)C
InChI
1S/C27H40O3/c1-8-9-10-11-15-30-27-24(20(4)5)17-23(19(2)3)18-25(27)22(7)14-12-13-21(6)16-26(28)29/h12-14,16-20H,8-11,15H2,1-7H3,(H,28,29)/b13-12+,21-16+,22-14-
InChIKey
VTUYATVOWGSQFU-AQIGWABESA-N
PubChem Compound ID
9887925
Target and Pathway
Target(s) Bile acid receptor Target Info Inhibitor [527690]
Retinoic acid receptor RXR-gamma Target Info Inhibitor [527690]
Retinoic acid receptor RXR-alpha Target Info Inhibitor [527690]
Retinoid X receptor-beta Target Info Inhibitor [527690]
KEGG Pathway Bile secretionhsa03320:PPAR signaling pathway
Thyroid hormone signaling pathway
Adipocytokine signaling pathway
Pathways in cancer
Transcriptional misregulation in cancer
Thyroid cancer
Small cell lung cancer
Non-small cell lung cancerhsa03320:PPAR signaling pathway
PI3K-Akt signaling pathway
Non-alcoholic fatty liver disease (NAFLD)
Bile secretion
Hepatitis C
Non-small cell lung cancer
PANTHER Pathway Vitamin D metabolism and pathway
Pathway Interaction Database RXR and RAR heterodimerization with other nuclear receptorar_tf_pathway:Regulation of Androgen receptor activity
RXR and RAR heterodimerization with other nuclear receptor
Retinoic acid receptors-mediated signaling
a6b1 and a6b4 Integrin signalingar_tf_pathway:Regulation of Androgen receptor activity
a6b1 and a6b4 Integrin signaling
Reactome Recycling of bile acids and salts
PPARA activates gene expression
Endogenous sterolsR-HSA-383280:Nuclear Receptor transcription pathwayR-HSA-1368082:RORA activates gene expression
BMAL1:CLOCK,NPAS2 activates circadian gene expression
Import of palmitoyl-CoA into the mitochondrial matrix
YAP1- and WWTR1 (TAZ)-stimulated gene expression
Regulation of pyruvate dehydrogenase (PDH) complex
Endogenous sterols
Transcriptional activation of mitochondrial biogenesis
Activation of gene expression by SREBF (SREBP)
Transcriptional regulation of white adipocyte differentiation
Nuclear Receptor transcription pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Circadian Clock
WikiPathways Nuclear Receptors in Lipid Metabolism and Toxicity
Nuclear Receptors Meta-Pathway
Farnesoid X Receptor Pathway
Drug Induction of Bile Acid PathwayWP716:Vitamin A and Carotenoid Metabolism
Adipogenesis
Nuclear ReceptorsWP716:Vitamin A and Carotenoid Metabolism
NRF2 pathway
PPAR Alpha Pathway
Vitamin D Receptor Pathway
Pregnane X Receptor pathway
Constitutive Androstane Receptor Pathway
Liver X Receptor Pathway
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Transcriptional Regulation of White Adipocyte Differentiation
YAP1- and WWTR1 (TAZ)-stimulated gene expression
Activation of Gene Expression by SREBP (SREBF)
Integrated Pancreatic Cancer Pathway
Circadian Clock
Nuclear Receptors
Vitamin D Metabolism
References
Ref 527690J Med Chem. 2005 Aug 25;48(17):5383-403.Farnesoid X receptor: from structure to potential clinical applications.
Ref 527690J Med Chem. 2005 Aug 25;48(17):5383-403.Farnesoid X receptor: from structure to potential clinical applications.

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