TTD | Drug: D0N1PH

Drug General Information
Drug ID	D0N1PH
Former ID	DIB021249
Drug Name	YM49598
Synonyms	YM-49598
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[539346]
Structure		Download 2D MOL
Formula	C36H45Cl2N2O2+
InChI	InChI=1S/C36H45Cl2N2O2/c1-27(2)42-32-12-7-9-28(23-32)24-35(41)39-19-8-17-36(26-39,31-13-14-33(37)34(38)25-31)18-22-40(3)20-15-30(16-21-40)29-10-5-4-6-11-29/h4-7,9-14,23,25,27,30H,8,15-22,24,26H2,1-3H3/q+1
InChIKey	QRSSYNAUQYYMPH-UHFFFAOYSA-N
PubChem Compound ID	10327625
PubChem Substance ID	33960696, 76086665, 135651349
Target and Pathway
Target(s)	NK-2 receptor	Target Info	Antagonist	[526310]
KEGG Pathway	Calcium signaling pathway
KEGG Pathway	Neuroactive ligand-receptor interaction
Reactome	G alpha (q) signalling events
WikiPathways	Gastrin-CREB signalling pathway via PKC and MAPK
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 539346	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2122).
Ref 526310	Effect of YM-44781, YM-44778 and YM-49598, novel tachykinin antagonists, in a drug-induced bladder contraction model. Pharmacology. 2002 May;65(2):96-102.

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Drug Information