Drug Information

Drug General Information
Drug ID
D0W8RB
Former ID
DNC008814
Drug Name
8-Bromo-9-(but-3-enyl)-9H-adenine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530014]
Structure
Download
2D MOL

3D MOL
Formula
C9H10BrN5
Canonical SMILES
C=CCCN1C2=C(C(=NC=N2)N)N=C1Br
InChI
1S/C9H10BrN5/c1-2-3-4-15-8-6(14-9(15)10)7(11)12-5-13-8/h2,5H,1,3-4H2,(H2,11,12,13)
InChIKey
PZPGDJLTSOBNOR-UHFFFAOYSA-N
PubChem Compound ID
44572357
Target and Pathway
Target(s) Adenosine A1 receptor Target Info Inhibitor [530014]
Adenosine A2a receptor Target Info Inhibitor [530014]
KEGG Pathway cGMP-PKG signaling pathway
cAMP signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interaction
Morphine addictionhsa04015:Rap1 signaling pathway
Calcium signaling pathway
Vascular smooth muscle contraction
Parkinson's disease
Alcoholism
NetPath Pathway TCR Signaling Pathway
RANKL Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Pathway Interaction Database HIF-2-alpha transcription factor network
PathWhiz Pathway Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Reactome Adenosine P1 receptors
G alpha (i) signalling eventsR-HSA-187024:NGF-independant TRKA activation
G alpha (s) signalling events
Surfactant metabolism
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP80:Nucleotide GPCRs
Monoamine Transport
NGF signalling via TRKA from the plasma membrane
GPCR downstream signaling
GPCRs, Other
References
Ref 530014Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. Epub 2009 Feb 23.8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands.
Ref 530014Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. Epub 2009 Feb 23.8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.