Drug Information

Drug General Information
Drug ID
D06TSQ
Former ID
DIB020254
Drug Name
LUF5831
Synonyms
LUF 5831; LUF-5831
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540511]
Structure
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2D MOL

3D MOL
Formula
C15H12N4O2S
InChI
InChI=1S/C15H12N4O2S/c16-7-11-13(9-1-3-10(21)4-2-9)12(8-17)15(19-14(11)18)22-6-5-20/h1-4,20-21H,5-6H2,(H2,18,19)
InChIKey
GYIHPWFWFRELQC-UHFFFAOYSA-N
PubChem Compound ID
9948668
PubChem Substance ID
14923428, 37369515, 77360036, 103440048, 104049456, 135650538, 139402308, 224060476, 230251621, 243468908
Target and Pathway
Target(s) Adenosine A1 receptor Target Info Agonist [527992]
KEGG Pathway cGMP-PKG signaling pathway
cAMP signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interaction
Morphine addiction
NetPath Pathway TCR Signaling Pathway
RANKL Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome Adenosine P1 receptors
G alpha (i) signalling events
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 540511(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 376).
Ref 527992Allosteric modulation, thermodynamics and binding to wild-type and mutant (T277A) adenosine A1 receptors of LUF5831, a novel nonadenosine-like agonist. Br J Pharmacol. 2006 Mar;147(5):533-41.

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