Drug General Information
Drug ID	D08AJS
Former ID	DNC005879
Drug Name	3-(3-chloro-1H-pyrazol-5-yl)quinoxalin-2(1H)-one
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[529313]
Structure		Download 2D MOL 3D MOL
Formula	C11H7ClN4O
Canonical SMILES	C1=CC2=NC(=C3C=C(NN3)Cl)C(=O)N=C2C=C1
InChI	1S/C11H7ClN4O/c12-9-5-8(15-16-9)10-11(17)14-7-4-2-1-3-6(7)13-10/h1-5,15-16H/b10-8-
InChIKey	IBGKQIYBXOKNFP-NTMALXAHSA-N
PubChem Compound ID	11139437
Target and Pathway
Target(s)	Adenosine A3 receptor	Target Info	Inhibitor	[529313]
	Adenosine A1 receptor	Target Info	Inhibitor	[529313]
KEGG Pathway	cGMP-PKG signaling pathway
	cAMP signaling pathway
	Sphingolipid signaling pathway
	Neuroactive ligand-receptor interaction
	Morphine addiction
NetPath Pathway	TCR Signaling Pathway
	RANKL Signaling Pathway
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome	Adenosine P1 receptors
	G alpha (i) signalling eventsR-HSA-417973:Adenosine P1 receptors
	G alpha (i) signalling events
WikiPathways	Nucleotide GPCRs
	GPCRs, Class A Rhodopsin-like
	GPCRs, OtherWP80:Nucleotide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 529313	J Med Chem. 2008 Mar 27;51(6):1764-70. Epub 2008 Feb 13.Derivatives of 4-amino-6-hydroxy-2-mercaptopyrimidine as novel, potent, and selective A3 adenosine receptor antagonists.
Ref 529313	J Med Chem. 2008 Mar 27;51(6):1764-70. Epub 2008 Feb 13.Derivatives of 4-amino-6-hydroxy-2-mercaptopyrimidine as novel, potent, and selective A3 adenosine receptor antagonists.

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