Drug Information

Drug General Information
Drug ID
D07BKU
Former ID
DNC008975
Drug Name
A-795614
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529652]
Structure
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2D MOL

3D MOL
Formula
C22H25N5O
Canonical SMILES
C1CCN(CC1)C2=CC3=C(C=C2)C(CC3)NC(=O)NC4=CC=CC5=C4C=NN5
InChI
1S/C22H25N5O/c28-22(24-19-5-4-6-21-18(19)14-23-26-21)25-20-10-7-15-13-16(8-9-17(15)20)27-11-2-1-3-12-27/h4-6,8-9,13-14,20H,1-3,7,10-12H2,(H,23,26)(H2,24,25,28)/t20-/m1/s1
InChIKey
SVYGRCSOIPQXGO-HXUWFJFHSA-N
PubChem Compound ID
11451659
Target and Pathway
Target(s) Vanilloid receptor Target Info Inhibitor [529652]
Vanilloid receptor 1 Target Info Inhibitor [529652]
KEGG Pathway Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
NetPath Pathway IL2 Signaling Pathway
Pathway Interaction Database Trk receptor signaling mediated by the MAPK pathway
Trk receptor signaling mediated by PI3K and PLC-gamma
Reactome TRP channels
References
Ref 529652Bioorg Med Chem. 2008 Sep 15;16(18):8516-25. Epub 2008 Aug 7.Tetrahydropyridine-4-carboxamides as novel, potent transient receptor potential vanilloid 1 (TRPV1) antagonists.
Ref 529652Bioorg Med Chem. 2008 Sep 15;16(18):8516-25. Epub 2008 Aug 7.Tetrahydropyridine-4-carboxamides as novel, potent transient receptor potential vanilloid 1 (TRPV1) antagonists.

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