Drug Information

Drug General Information
Drug ID
D0T8SD
Former ID
DIB018555
Drug Name
2-hydroxy-saclofen
Synonyms
2-hydroxy-s-(-)-saclofen; 2-OH-saclofen; 2-hydroxysaclofen
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538650]
Structure
Download
2D MOL
Formula
C9H12ClNO4S
InChI
InChI=1S/C9H12ClNO4S/c10-8-3-1-7(2-4-8)9(12,5-11)6-16(13,14)15/h1-4,12H,5-6,11H2,(H,13,14,15)
InChIKey
WBSMZVIMANOCNX-UHFFFAOYSA-N
PubChem Compound ID
1564
PubChem Substance ID
5622930, 7978578, 8151184, 15417339, 17404642, 24278170, 24439891, 24895428, 48334723, 48484010, 49880200, 50104362, 50104363, 53777185, 57320942, 79105089, 85083623, 85230916, 85788093, 90341474, 91703035, 92303657, 104298083, 121361103, 123087479, 124558811, 124749429, 124879238, 126407141, 129558641, 134222192, 135065499, 135374404, 135649709, 142796829, 152053676, 162022513, 162092009, 163124459, 163564033, 204408868, 226675882, 241181592, 242426430, 252332891
Target and Pathway
Target(s) GABAB receptor Target Info Antagonist [534343]
Gamma-aminobutyric acid B receptor Target Info Antagonist [534343]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
GABAergic synapse
Estrogen signaling pathway
Morphine addiction
Reactome Activation of G protein gated Potassium channels
G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
WikiPathways GPCRs, Class C Metabotropic glutamate, pheromone
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Potassium Channels
GPCR ligand binding
GPCR downstream signaling
References
Ref 538650(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1068).
Ref 534343Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors. Nature. 1997 Mar 20;386(6622):239-46.

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