Drug Information

Drug General Information
Drug ID
D0R6MT
Former ID
DIB020081
Drug Name
isobutylmethylxanthine
Synonyms
methylisobutylxanthine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540528]
Structure
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2D MOL

3D MOL
Formula
C10H14N4O2
InChI
InChI=1S/C10H14N4O2/c1-6(2)4-14-8-7(11-5-12-8)9(15)13(3)10(14)16/h5-6H,4H2,1-3H3,(H,11,12)
InChIKey
APIXJSLKIYYUKG-UHFFFAOYSA-N
PubChem Compound ID
3758
PubChem Substance ID
440021, 586297, 603446, 831838, 3139713, 4667750, 4667751, 6436339, 7888298, 7980296, 8150163, 8152377, 10517163, 11111325, 11120336, 11120824, 11121312, 11121752, 11122232, 11336097, 11361336, 11362907, 11364974, 11365469, 11367536, 11368031, 11370098, 11371005, 11371006, 11372975, 11373137, 11373632, 11374483, 11375698, 11376193, 11378269, 11404372, 11462308, 11485426, 11485546, 11489521, 11489551, 11491773, 11492866, 12157646, 14822728, 15195998, 17405203, 24277680, 24896107
Target and Pathway
Target(s) Adenosine A1 receptor Target Info Antagonist [533744]
KEGG Pathway cGMP-PKG signaling pathway
cAMP signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interaction
Morphine addiction
NetPath Pathway TCR Signaling Pathway
RANKL Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome Adenosine P1 receptors
G alpha (i) signalling events
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 540528(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 388).
Ref 533744Species difference in the G protein selectivity of the human and bovine A1-adenosine receptor. J Biol Chem. 1994 Dec 23;269(51):32077-84.

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