Drug General Information
Drug ID	D0NJ4G
Former ID	DNC007192
Drug Name	5,7-dichloro-1H-indole-2,3-dione
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[528749]
Structure		Download 2D MOL 3D MOL
Formula	C8H3Cl2NO2
Canonical SMILES	C1=C(C=C2C(=C1Cl)NC(=O)C2=O)Cl
InChI	1S/C8H3Cl2NO2/c9-3-1-4-6(5(10)2-3)11-8(13)7(4)12/h1-2H,(H,11,12,13)
InChIKey	AYGGQJHJRFZDFH-UHFFFAOYSA-N
PubChem Compound ID	80771
Target and Pathway
Target(s)	Liver carboxylesterase	Target Info	Inhibitor	[528749]
KEGG Pathway	Drug metabolism - other enzymes
	Metabolic pathways
Pathway Interaction Database	E2F transcription factor network
WikiPathways	NRF2 pathway
	Nuclear Receptors Meta-Pathway
	Heroin metabolism
	Irinotecan Pathway
	Fluoropyrimidine Activity
	Phase I biotransformations, non P450
References
Ref 528749	J Med Chem. 2007 Apr 19;50(8):1876-85. Epub 2007 Mar 23.Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.
Ref 528749	J Med Chem. 2007 Apr 19;50(8):1876-85. Epub 2007 Mar 23.Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.

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