TTD | Drug: D03OGA

Drug General Information
Drug ID	D03OGA
Former ID	DIB018563
Drug Name	2-methoxy-alpha,beta-didehydro-agomelatine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[542727]
Structure		Download 2D MOL
Formula	C16H17NO3
InChI	InChI=1S/C16H17NO3/c1-11(18)17-9-8-14-15-10-13(19-2)6-4-12(15)5-7-16(14)20-3/h4-10H,1-3H3,(H,17,18)/b9-8+
InChIKey	HMYFXYOFPXZULT-CMDGGOBGSA-N
PubChem Compound ID	71533431
PubChem Substance ID	163529101, 164142147, 164154077, 223366108
Target and Pathway
Target(s)	Melatonin receptor	Target Info	Agonist	[532164]
KEGG Pathway	Neuroactive ligand-receptor interaction
KEGG Pathway	Circadian entrainment
Reactome	Class A/1 (Rhodopsin-like receptors)
Reactome	G alpha (i) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Small Ligand GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 542727	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7775).
Ref 532164	Synthesis of new N-(arylcyclopropyl)acetamides and N-(arylvinyl)acetamides as conformationally-restricted ligands for melatonin receptors. Bioorg Med Chem Lett. 2013 Jan 15;23(2):430-4.

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Drug Information