Drug Information

Drug General Information
Drug ID
D0D2FP
Former ID
DIB018229
Drug Name
[3H]A778317
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540670]
Structure
Download
2D MOL
Formula
C23H25N3O
InChI
InChI=1S/C23H25N3O/c1-23(2,3)17-8-9-18-15(13-17)7-10-21(18)26-22(27)25-20-6-4-5-16-14-24-12-11-19(16)20/h4-6,8-9,11-14,21H,7,10H2,1-3H3,(H2,25,26,27)/t21-/m1/s1/i5T,6T
InChIKey
VPSCJCQPUGKRNC-ZVVBTKFUSA-N
PubChem Compound ID
53321936
PubChem Substance ID
124966737, 178100899
Target and Pathway
Target(s) Vanilloid receptor 1 Target Info Blocker (channel blocker) [528966]
KEGG Pathway Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
NetPath Pathway IL2 Signaling Pathway
Pathway Interaction Database Trk receptor signaling mediated by the MAPK pathway
Trk receptor signaling mediated by PI3K and PLC-gamma
Reactome TRP channels
References
Ref 540670(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4076).
Ref 528966[3H]A-778317 [1-((R)-5-tert-butyl-indan-1-yl)-3-isoquinolin-5-yl-urea]: a novel, stereoselective, high-affinity antagonist is a useful radioligand for the human transient receptor potential vanilloid-1 (TRPV1) receptor. J Pharmacol Exp Ther. 2007 Oct;323(1):285-93. Epub 2007 Jul 27.

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