Drug Information

Drug General Information
Drug ID
D0I6YD
Former ID
DIB019004
Drug Name
BPH-252
Synonyms
BPH 252; BPH252
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540176]
Structure
Download
2D MOL
Formula
C10H24O7P2
InChI
InChI=1S/C10H24O7P2/c1-2-3-4-5-6-7-8-9-10(11,18(12,13)14)19(15,16)17/h11H,2-9H2,1H3,(H2,12,13,14)(H2,15,16,17)
InChIKey
NSCPCMXKWUFFNL-UHFFFAOYSA-N
PubChem Compound ID
5276503
PubChem Substance ID
7842856, 8614897, 14752559, 39285934, 56374410, 74958776, 103240822, 113842593, 128746742, 135650015, 234888761
Target and Pathway
Target(s) Geranyltranstransferase Target Info Inhibitor [529700]
BioCyc Pathway Superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)
Superpathway of cholesterol biosynthesis
Trans, trans-farnesyl diphosphate biosynthesis
Geranylgeranyldiphosphate biosynthesis
KEGG Pathway Terpenoid backbone biosynthesis
Metabolic pathways
Biosynthesis of antibiotics
PANTHER Pathway Cholesterol biosynthesis
PathWhiz Pathway Steroid Biosynthesis
Reactome Cholesterol biosynthesis
Activation of gene expression by SREBF (SREBP)
WikiPathways Activation of Gene Expression by SREBP (SREBF)
References
Ref 540176(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3198).
Ref 529700Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation. J Med Chem. 2008 Sep 25;51(18):5594-607.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.