Drug General Information
Drug ID	D01OMG
Former ID	DIB020576
Drug Name	NS9283
Synonyms	NS-9283
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[540609]
Structure		Download 2D MOL
Formula	C14H8N4O
InChI	InChI=1S/C14H8N4O/c15-8-10-3-1-4-11(7-10)14-17-13(18-19-14)12-5-2-6-16-9-12/h1-7,9H
InChIKey	HGFXDSQLRSWUBO-UHFFFAOYSA-N
PubChem Compound ID	11998180
PubChem Substance ID	17497342, 24500684, 37446558, 79321301, 141669600, 178100819, 188377297, 188377299, 194173553, 194943507, 224189866, 227634345, 242896807, 249691401, 249896026, 252158608
Target and Pathway
Target(s)	Neuronal acetylcholine receptor protein, beta-2 chain	Target Info	Modulator (allosteric modulator)	[531561]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Cholinergic synapse
	Nicotine addiction
PANTHER Pathway	Nicotinic acetylcholine receptor signaling pathway
	Nicotine pharmacodynamics pathway
Reactome	Highly sodium permeable acetylcholine nicotinic receptors
	Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
	Highly calcium permeable nicotinic acetylcholine receptors
WikiPathways	SIDS Susceptibility Pathways
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Nicotine Activity on Dopaminergic Neurons
References
Ref 540609	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3993).
Ref 531561	alpha4beta2 neuronal nicotinic receptor positive allosteric modulation: an approach for improving the therapeutic index of alpha4beta2 nAChR agonists in pain. Biochem Pharmacol. 2011 Oct 15;82(8):959-66.

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