Drug General Information
Drug ID
D02UUO
Former ID
DIB019743
Drug Name
dihydrosphingosine-1-phosphate
Synonyms
sphinganine 1-phosphate; sphinganine-phosphate; dihydroS1P
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539938]
Structure
Download
2D MOL
Formula
C18H40NO5P
InChI
InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/t17-,18+/m0/s1
InChIKey
YHEDRJPUIRMZMP-ZWKOTPCHSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) S1P4 receptor Target Info Agonist [526430]
GPR63 Target Info Agonist [526565]
References
Ref 539938(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2921).
Ref 526430Phytosphingosine 1-phosphate: a high affinity ligand for the S1P(4)/Edg-6 receptor. Biochem Biophys Res Commun. 2002 Sep 27;297(3):600-6.
Ref 526565Sphingosine 1-phosphate and dioleoylphosphatidic acid are low affinity agonists for the orphan receptor GPR63. Cell Signal. 2003 Apr;15(4):435-46.

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