Drug Information
Drug General Information | |||||
---|---|---|---|---|---|
Drug ID |
D0G9WE
|
||||
Former ID |
DIB018944
|
||||
Drug Name |
batrachotoxin
|
||||
Drug Type |
Small molecular drug
|
||||
Indication | Discovery agent | Investigative | [539690] | ||
Structure |
Download2D MOL |
||||
Formula |
C31H42N2O6
|
||||
InChI |
InChI=1S/C31H42N2O6/c1-18-16-32-19(2)25(18)26(35)38-20(3)22-8-9-30-23-7-6-21-14-29(36)11-10-27(21,4)31(23,39-29)24(34)15-28(22,30)17-33(5)12-13-37-30/h7-8,16,20-21,24,32,34,36H,6,9-15,17H2,1-5H3/t20-,21+,24+,27-,28-,29+,30-,31-/m0/s1
|
||||
InChIKey |
ISNYUQWBWALXEY-OMIQOYQYSA-N
|
||||
PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | SCN8A sodium channel subunit | Target Info | Activator | [543883] | |
Sodium channel protein type 2 subunit alpha | Target Info | Activator | [534744] | ||
Voltage-gated sodium channel subunit alpha Nav1.3 | Target Info | Activator | [543881] | ||
mRNA of SCN1A | Target Info | Activator | [543880] | ||
Voltage-gated sodium channel subunit alpha Nav1.7 | Target Info | Activator | [543884] | ||
Voltage-gated sodium channel subunit alpha Nav1.8 | Target Info | Activator | [527277] | ||
Sodium channel protein type 4 subunit alpha | Target Info | Activator | [534563] | ||
Sodium channel protein type 5 subunit alpha | Target Info | Activator | [532575] | ||
PathWhiz Pathway | Muscle/Heart Contraction | ||||
References | |||||
Ref 527277 | The poison Dart frog's batrachotoxin modulates Nav1.8. FEBS Lett. 2004 Nov 5;577(1-2):245-8. | ||||
Ref 532575 | Binding of [3H]batrachotoxinin A benzoate to specific sites on rat cardiac sodium channels. Mol Pharmacol. 1986 Dec;30(6):617-23. | ||||
Ref 534563 | Point mutations in segment I-S6 render voltage-gated Na+ channels resistant to batrachotoxin. Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2653-8. | ||||
Ref 534744 | Interaction of batrachotoxin with the local anesthetic receptor site in transmembrane segment IVS6 of the voltage-gated sodium channel. Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13947-52. | ||||
Ref 543880 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 578). | ||||
Ref 543881 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 580). | ||||
Ref 543883 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 583). | ||||
Ref 543884 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 584). |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.