Drug General Information
Drug ID
D02NZI
Former ID
DIB020962
Drug Name
SM-130,686
Synonyms
SM 130686
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541175]
Structure
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2D MOL

3D MOL

Formula
C22H23ClF3N3O3
InChI
InChI=1S/C22H23ClF3N3O3/c1-3-28(4-2)9-10-29-17-12-13(19(27)30)11-15(22(24,25)26)18(17)21(32,20(29)31)14-7-5-6-8-16(14)23/h5-8,11-12,32H,3-4,9-10H2,1-2H3,(H2,27,30)/t21-/m1/s1
InChIKey
YSSPGXCFFITNCE-OAQYLSRUSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Growth hormone secretagogue receptor type 1 Target Info Agonist [526224]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
NetPath Pathway Leptin Signaling Pathway
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 541175(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5866).
Ref 526224Oxindole derivatives as orally active potent growth hormone secretagogues. J Med Chem. 2001 Dec 20;44(26):4641-9.

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