Drug Information

Drug General Information
Drug ID
D06VRA
Former ID
DNC008412
Drug Name
4,17-dehydroxyriccardin C
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529375]
Structure
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2D MOL

3D MOL
Formula
C28H24O2
Canonical SMILES
C1CC2=CC=CC=C2C3=C(C=C(CCC4=CC(=CC=C4)OC5=CC=C1C=C5)C=C<br />3)O
InChI
1S/C28H24O2/c29-28-19-22-9-8-21-4-3-6-25(18-21)30-24-15-11-20(12-16-24)10-14-23-5-1-2-7-26(23)27(28)17-13-22/h1-7,11-13,15-19,29H,8-10,14H2
InChIKey
AWANYYTXBZWDHH-UHFFFAOYSA-N
PubChem Compound ID
24860515
Target and Pathway
Target(s) Oxysterols receptor LXR-alpha Target Info Inhibitor [529375]
Oxysterols receptor LXR-beta Target Info Inhibitor [529375]
KEGG Pathway PPAR signaling pathway
Non-alcoholic fatty liver disease (NAFLD)
Hepatitis C
Pathway Interaction Database RXR and RAR heterodimerization with other nuclear receptorrxr_vdr_pathway:RXR and RAR heterodimerization with other nuclear receptor
Reactome Nuclear Receptor transcription pathway
WikiPathways Nuclear Receptors in Lipid Metabolism and Toxicity
Nuclear Receptors Meta-Pathway
PPAR Alpha Pathway
Liver X Receptor Pathway
Adipogenesis
SREBF and miR33 in cholesterol and lipid homeostasis
Nuclear ReceptorsWP1982:SREBP signalling
Nuclear Receptors
References
Ref 529375Bioorg Med Chem. 2008 Apr 15;16(8):4272-85. Epub 2008 Feb 29.Co-existence of alpha-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development.
Ref 529375Bioorg Med Chem. 2008 Apr 15;16(8):4272-85. Epub 2008 Feb 29.Co-existence of alpha-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development.

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