Drug Information

Drug General Information
Drug ID
D00ZXX
Former ID
DIB019679
Drug Name
CYM5442
Synonyms
CYM-5442
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539945]
Structure
Download
2D MOL
Formula
C23H27N3O4
InChI
InChI=1S/C23H27N3O4/c1-3-28-20-11-8-15(14-21(20)29-4-2)23-25-22(26-30-23)18-7-5-6-17-16(18)9-10-19(17)24-12-13-27/h5-8,11,14,19,24,27H,3-4,9-10,12-13H2,1-2H3
InChIKey
NUIKTBLZSPQGCP-UHFFFAOYSA-N
PubChem Compound ID
25110406
PubChem Substance ID
56432519, 85240671, 89867291, 112629139, 135650150, 138601891, 140449915, 162248415, 223654525, 227627048, 246038057, 252215222, 252450636
Target and Pathway
Target(s) Sphingosine 1-phosphate receptor 1 Target Info Agonist [529645]
KEGG Pathway FoxO signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interaction
NetPath Pathway IL4 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
IL2 Signaling Pathway
Pathway Interaction Database Fc-epsilon receptor I signaling in mast cells
S1P3 pathway
S1P1 pathway
Sphingosine 1-phosphate (S1P) pathway
PDGFR-beta signaling pathway
Reactome G alpha (i) signalling events
Lysosphingolipid and LPA receptors
WikiPathways Signal Transduction of S1P Receptor
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 539945(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2928).
Ref 529645Full pharmacological efficacy of a novel S1P1 agonist that does not require S1P-like headgroup interactions. Mol Pharmacol. 2008 Nov;74(5):1308-18.

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