Drug Information

Drug General Information
Drug ID
D0T0KA
Former ID
DAP000486
Drug Name
Nicardipine
Synonyms
Nicardipino; Nicardipinum; Cardene IV; Nicardipine LA; Cardene (TN); Nicardipine (INN); Nicardipine [INN:BAN]; Nicardipino [INN-Spanish]; Nicardipinum [INN-Latin]; Y-93; Methyl 2-[methyl(phenylmethyl)amino]ethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; 2-(Benzylmethylamino)ethylmethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)pyridine-3,5-dicarboxylate; 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-(benzylmethylamino)ethyl methyl ester; 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl 2-(methyl(phenylmethyl)amino)ethyl ester; 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl 2-[methyl(phenylmethyl)amino]ethyl ester; 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-,2-(benzylmethylamino)ethyl methyl ester; 5-O-[2-[benzyl(methyl)amino]ethyl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Drug Type
Small molecular drug
Indication High blood pressure; Angina [ICD9: 401, 413; ICD10:I10, I11, I12, I13, I15, I20] Approved [538588], [539652]
Therapeutic Class
Antihypertensive Agents
Company
Chiesi Usa Inc
Structure
Download
2D MOL

3D MOL
Formula
C26H29N3O6
InChI
InChI=1S/C26H29N3O6/c1-17-22(25(30)34-4)24(20-11-8-12-21(15-20)29(32)33)23(18(2)27-17)26(31)35-14-13-28(3)16-19-9-6-5-7-10-19/h5-12,15,24,27H,13-14,16H2,1-4H3
InChIKey
ZBBHBTPTTSWHBA-UHFFFAOYSA-N
CAS Number
CAS 55985-32-5
PubChem Compound ID
4474
PubChem Substance ID
9473, 6300545, 7578094, 7980119, 8152757, 11119969, 11120457, 11120945, 11121454, 11121934, 11147052, 11335715, 11360954, 11362523, 11364266, 11365085, 11366828, 11367647, 11369390, 11370317, 11370318, 11372542, 11373248, 11373883, 11375809, 11377552, 11461926, 11466411, 11467531, 11485226, 11486222, 11489231, 11491267, 11492237, 11495186, 14907905, 26755701, 26755702, 29223569, 46504482, 47216524, 47216525, 47515065, 47588738, 47810485, 47810486, 47810487, 47810488, 48034827, 48184723
SuperDrug ATC ID
C08CA04
SuperDrug CAS ID
cas=055985325
Target and Pathway
Target(s) Calcium channel Target Info Blocker [537568]
References
Ref 538588FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 022276.
Ref 539652(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2559).
Ref 537568Effect of intracoronary nicardipine on cardiac enzymes after elective percutaneous coronary intervention. Clin Cardiol. 2009 Jun;32(6):315-20.

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