Drug General Information
Drug ID
D0L3EP
Former ID
DIB019945
Drug Name
GSK1614343
Synonyms
GSK-1614343; GSK 1614343
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541179]
Structure
Download
2D MOL
Formula
C22H23F6N5O
InChI
InChI=1S/C22H23F6N5O/c23-21(24,25)15-9-16(22(26,27)28)11-17(10-15)30-31-20(34)19(14-3-1-5-29-12-14)33-8-7-32-6-2-4-18(32)13-33/h1,3,5,9-12,18-19,30H,2,4,6-8,13H2,(H,31,34)/t18-,19-/m1/s1
InChIKey
QNOSCJDGJKVFJR-RTBURBONSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Growth hormone secretagogue receptor type 1 Target Info Antagonist [531003]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
NetPath Pathway Leptin Signaling Pathway
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 541179(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5870).
Ref 531003Discovery process and characterization of novel carbohydrazide derivatives as potent and selective GHSR1a antagonists. ChemMedChem. 2010 Sep 3;5(9):1450-5.

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