| Drug General Information |
| Drug ID |
D0C0VP
|
| Former ID |
DNC003912
|
| Drug Name |
Cyclostellettamine derivative
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C40H58F6N2O4
|
| Canonical SMILES |
C1CCCCCC[N+]2=CC=CC(=C2)CCCCCCC=CCCCCCC[N+]3=CC=CC(=C3)<br />CCCCC1.C(=O)(C(F)(F)F)[O-].C(=O)(C(F)(F)F)[O-]
|
| InChI |
1S/C36H58N2.2C2HF3O2/c1-2-5-9-13-17-21-29-37-31-24-28-36(34-37)26-20-16-12-8-4-6-10-14-18-22-30-38-32-23-27-35(33-38)25-19-15-11-7-3-1;2*3-2(4,5)1(6)7/h1-2,23-24,27-28,31-34H,3-22,25-26,29-30H2;2*(H,6,7)/q+2;;/p-2/b2-1+;;
|
| InChIKey |
LUAUOMZCZVKFMM-SEPHDYHBSA-L
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Histone Deacetylase 10 |
Target Info |
Inhibitor |
[1]
|
|---|
| Histone deacetylase 2 |
Target Info |
Inhibitor |
[1]
|
| Histone deacetylase |
Target Info |
Inhibitor |
[1]
|
| Histone deacetylase 4 |
Target Info |
Inhibitor |
[1]
|
| Histone deacetylase 6 |
Target Info |
Inhibitor |
[1]
|
| Histone deacetylase 1 |
Target Info |
Inhibitor |
[1]
|
| Histone Deacetylase 8 |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
Cell cycle
|
|
Notch signaling pathway
|
|
Thyroid hormone signaling pathway
|
|
Huntington's disease
|
|
Alcoholism
|
|
Epstein-Barr virus infection
|
|
Pathways in cancer
|
|
Transcriptional misregulation in cancer
|
|
Viral carcinogenesis
|
|
Chronic myeloid leukemiahsa05034:Alcoholism
|
|
MicroRNAs in cancerhsa05034:Alcoholism
|
|
Viral carcinogenesishsa04110:Cell cycle
|
|
Amphetamine addiction
|
|
MicroRNAs in cancer
|
|
NetPath Pathway
|
TCR Signaling PathwayNetPath_14:IL2 Signaling PathwayNetPath_11:TCR Signaling Pathway
|
|
PANTHER Pathway
|
Wnt signaling pathwayP00057:Wnt signaling pathway
|
|
p53 pathwayP00057:Wnt signaling pathway
|
|
Pathway Interaction Database
|
Signaling events mediated by HDAC Class II
|
|
Signaling events mediated by HDAC Class Ismad2_3nuclearpathway:Regulation of nuclear SMAD2/3 signaling
|
|
Signaling events mediated by HDAC Class I
|
|
Regulation of Telomerase
|
|
Glucocorticoid receptor regulatory network
|
|
Direct p53 effectors
|
|
Hedgehog signaling events mediated by Gli proteins
|
|
Regulation of nuclear beta catenin signaling and target gene transcriptionhdac_classii_pathway:Signaling events mediated by HDAC Class II
|
|
Signaling events mediated by HDAC Class III
|
|
Sumoylation by RanBP2 regulates transcriptional repression
|
|
Validated nuclear estrogen receptor alpha networkhdac_classii_pathway:Signaling events mediated by HDAC Class II
|
|
Notch signaling pathway
|
|
E2F transcription factor network
|
|
Presenilin action in Notch and Wnt signaling
|
|
Regulation of Androgen receptor activity
|
|
IL3-mediated signaling events
|
|
Validated nuclear estrogen receptor alpha network
|
|
Retinoic acid receptors-mediated signaling
|
|
Regulation of nuclear beta catenin signaling and target gene transcription
|
|
Validated targets of C-MYC transcriptional repression
|
|
Regulation of retinoblastoma protein
|
|
Notch-mediated HES/HEY networkhdac_classi_pathway:Signaling events mediated by HDAC Class I
|
|
Reactome
|
p75NTR negatively regulates cell cycle via SC1
|
|
NOTCH1 Intracellular Domain Regulates Transcription
|
|
Constitutive Signaling by NOTCH1 PEST Domain Mutants
|
|
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
|
|
HDACs deacetylate histones
|
|
NoRC negatively regulates rRNA expression
|
|
RNA Polymerase I Transcription Initiation
|
|
Factors involved in megakaryocyte development and platelet productionR-HSA-2122947:NOTCH1 Intracellular Domain Regulates Transcription
|
|
Constitutive Signaling by NOTCH1 HD+PEST Domain MutantsR-HSA-2122947:NOTCH1 Intracellular Domain Regulates Transcription
|
|
Assembly of the primary ciliumR-HSA-1538133:G0 and Early G1
|
|
Formation of the beta-catenin:TCF transactivating complex
|
|
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
|
|
Deactivation of the beta-catenin transactivating complex
|
|
WikiPathways
|
Notch Signaling Pathway
|
|
Notch Signaling Pathway
|
|
Neural Crest Differentiation
|
|
Signalling by NGF
|
|
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
|
|
Factors involved in megakaryocyte development and platelet production
|
|
Cell CycleWP474:Endochondral Ossification
|
|
Cardiac Hypertrophic Response
|
|
miR-targeted genes in muscle cell - TarBase
|
|
miR-targeted genes in lymphocytes - TarBase
|
|
miR-targeted genes in epithelium - TarBase
|
|
TarBasePathway
|
|
Cell Cycle
|
|
MicroRNAs in cardiomyocyte hypertrophyWP2858:Ectoderm Differentiation
|
|
Cell CycleWP706:SIDS Susceptibility Pathways
|
|
TGF beta Signaling Pathway
|
|
IL-6 signaling pathway
|
|
Apoptosis-related network due to altered Notch3 in ovarian cancer
|
|
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
|
|
Retinoblastoma (RB) in Cancer
|
|
TWEAK Signaling Pathway
|
|
Integrated Breast Cancer Pathway
|
|
Mitotic G1-G1/S phases
|
|
Androgen receptor signaling pathwayWP2377:Integrated Pancreatic Cancer Pathway
|
| References |
| REF 1 | Bioorg Med Chem Lett. 2004 May 17;14(10):2617-20.Three new cyclostellettamines, which inhibit histone deacetylase, from a marine sponge of the genus Xestospongia. |
|---|
