Drug Information

Drug General Information
Drug ID
D0C6QI
Former ID
DIB018751
Drug Name
acetyl-podocarpic dimer
Synonyms
acetyl podocarpic acid anhydride
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539798]
Structure
Download
2D MOL
Formula
C38H46O7
InChI
InChI=1S/C38H46O7/c1-23(39)43-27-13-9-25-11-15-31-35(3,29(25)21-27)17-7-19-37(31,5)33(41)45-34(42)38(6)20-8-18-36(4)30-22-28(44-24(2)40)14-10-26(30)12-16-32(36)38/h9-10,13-14,21-22,31-32H,7-8,11-12,15-20H2,1-6H3/t31-,32-,35-,36-,37+,38+/m1/s1
InChIKey
OUJQRQRBNRGQTC-SPGSYPTKSA-N
PubChem Compound ID
9830426
PubChem Substance ID
14789616, 15311161, 24131612, 44928547, 78898187, 103580326, 104098893, 135649888, 140154467, 231357895, 245238381, 252465792
Target and Pathway
Target(s) Oxysterols receptor LXR-alpha Target Info Agonist [526248]
Oxysterols receptor LXR-beta Target Info Agonist [526248]
KEGG Pathway PPAR signaling pathway
Non-alcoholic fatty liver disease (NAFLD)
Hepatitis C
Pathway Interaction Database RXR and RAR heterodimerization with other nuclear receptorrxr_vdr_pathway:RXR and RAR heterodimerization with other nuclear receptor
Reactome Nuclear Receptor transcription pathway
WikiPathways Nuclear Receptors in Lipid Metabolism and Toxicity
Nuclear Receptors Meta-Pathway
PPAR Alpha Pathway
Liver X Receptor Pathway
Adipogenesis
SREBF and miR33 in cholesterol and lipid homeostasis
Nuclear ReceptorsWP1982:SREBP signalling
Nuclear Receptors
References
Ref 539798(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2753).
Ref 526248A potent synthetic LXR agonist is more effective than cholesterol loading at inducing ABCA1 mRNA and stimulating cholesterol efflux. J Biol Chem. 2002 Mar 22;277(12):10021-7. Epub 2002 Jan 14.

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