Drug General Information
Drug ID
D0JV2P
Former ID
DIB019031
Drug Name
BTP2
Synonyms
YM-58483
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539566]
Structure
Download
2D MOL
Formula
C15H9F6N5OS
InChI
InChI=1S/C15H9F6N5OS/c1-7-12(28-25-23-7)13(27)22-8-2-4-9(5-3-8)26-11(15(19,20)21)6-10(24-26)14(16,17)18/h2-6H,1H3,(H,22,27)
InChIKey
XPRZIORDEVHURQ-UHFFFAOYSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Short transient receptor potential channel 3 Target Info Blocker (channel blocker) [527376]
TRPM4 Target Info Activator [527963]
TRP cation channel C5 Target Info Blocker (channel blocker) [543854]
PANTHER Pathway Alzheimer disease-presenilin pathway
Pathway Interaction Database Trk receptor signaling mediated by PI3K and PLC-gamma
Reactome Effects of PIP2 hydrolysis
TRP channels
Role of second messengers in netrin-1 signalingR-HSA-3295583:TRP channels
Role of second messengers in netrin-1 signaling
WikiPathways Platelet homeostasis
Netrin-1 signaling
GPCR downstream signaling
Effects of PIP2 hydrolysisWP1868:Netrin-1 signaling
References
Ref 539566(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2438).
Ref 527376A functional link between store-operated and TRPC channels revealed by the 3,5-bis(trifluoromethyl)pyrazole derivative, BTP2. J Biol Chem. 2005 Mar 25;280(12):10997-1006. Epub 2005 Jan 12.
Ref 527963A pyrazole derivative potently inhibits lymphocyte Ca2+ influx and cytokine production by facilitating transient receptor potential melastatin 4 channel activity. Mol Pharmacol. 2006 Apr;69(4):1413-20. Epub 2006 Jan 11.
Ref 543854(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 490).

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.