Drug General Information
Drug ID	D08GLJ
Former ID	DNC012414
Drug Name	1,3,8-Trimethyl-3,7-dihydro-purine-2,6-dione
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[533394]
Structure		Download 2D MOL 3D MOL
Formula	C8H10N4O2
Canonical SMILES	CC1=NC2=C(N1)C(=O)N(C(=O)N2C)C
InChI	1S/C8H10N4O2/c1-4-9-5-6(10-4)11(2)8(14)12(3)7(5)13/h1-3H3,(H,9,10)
InChIKey	WZBKGWBHAPBSBF-UHFFFAOYSA-N
PubChem Compound ID	95030
Target and Pathway
Target(s)	Adenosine A2a receptor	Target Info	Inhibitor	[533394]
KEGG Pathway	Rap1 signaling pathway
	Calcium signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Vascular smooth muscle contraction
	Parkinson's disease
	Alcoholism
Pathway Interaction Database	HIF-2-alpha transcription factor network
PathWhiz Pathway	Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Reactome	NGF-independant TRKA activation
	Adenosine P1 receptors
	G alpha (s) signalling events
	Surfactant metabolism
WikiPathways	Nucleotide GPCRs
	Monoamine Transport
	GPCRs, Class A Rhodopsin-like
	NGF signalling via TRKA from the plasma membrane
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, Other
References
Ref 533394	J Med Chem. 1985 Apr;28(4):487-92.1,3-Dialkyl-8-(p-sulfophenyl)xanthines: potent water-soluble antagonists for A1- and A2-adenosine receptors.
Ref 533394	J Med Chem. 1985 Apr;28(4):487-92.1,3-Dialkyl-8-(p-sulfophenyl)xanthines: potent water-soluble antagonists for A1- and A2-adenosine receptors.

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