Drug General Information
Drug ID
D03DEJ
Former ID
DIB018992
Drug Name
BMS614
Synonyms
BMS 614; BMS-614
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539709]
Structure
Download
2D MOL
Formula
C29H24N2O3
InChI
InChI=1S/C29H24N2O3/c1-29(2)14-13-23(21-15-19-5-3-4-6-26(19)30-17-21)24-16-20(9-12-25(24)29)27(32)31-22-10-7-18(8-11-22)28(33)34/h3-13,15-17H,14H2,1-2H3,(H,31,32)(H,33,34)
InChIKey
WGLMBRZXZDAQHP-UHFFFAOYSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Retinoic acid receptor alpha Target Info Antagonist [526251]
KEGG Pathway Pathways in cancer
Transcriptional misregulation in cancer
Acute myeloid leukemia
Pathway Interaction Database Retinoic acid receptors-mediated signaling
Reactome Nuclear Receptor transcription pathway
WikiPathways Vitamin A and Carotenoid Metabolism
Nuclear Receptors in Lipid Metabolism and Toxicity
Integrated Pancreatic Cancer Pathway
Adipogenesis
Nuclear Receptors
References
Ref 539709(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2643).
Ref 526251Co-regulator recruitment and the mechanism of retinoic acid receptor synergy. Nature. 2002 Jan 10;415(6868):187-92.

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