Drug Information

Drug General Information
Drug ID
D01WWK
Former ID
DIB018079
Drug Name
(2E, 6E)-farnesylbisphosphonate
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540180]
Structure
Download
2D MOL
Formula
C16H30O6P2
InChI
InChI=1S/C16H30O6P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-16(23(17,18)19)24(20,21)22/h7,9,11,16H,5-6,8,10,12H2,1-4H3,(H2,17,18,19)(H2,20,21,22)/b14-9+,15-11+
InChIKey
QBAOBDKNTDWTHR-YFVJMOTDSA-N
PubChem Compound ID
9871730
PubChem Substance ID
45293987, 50138127, 56240264, 79103778, 103294983, 135649700, 228944839, 234375876
Target and Pathway
Target(s) Geranyltranstransferase Target Info Inhibitor [529074]
BioCyc Pathway Superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)
Superpathway of cholesterol biosynthesis
Trans, trans-farnesyl diphosphate biosynthesis
Geranylgeranyldiphosphate biosynthesis
KEGG Pathway Terpenoid backbone biosynthesis
Metabolic pathways
Biosynthesis of antibiotics
PANTHER Pathway Cholesterol biosynthesis
PathWhiz Pathway Steroid Biosynthesis
Reactome Cholesterol biosynthesis
Activation of gene expression by SREBF (SREBP)
WikiPathways Activation of Gene Expression by SREBP (SREBF)
References
Ref 540180(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3200).
Ref 529074Mono- and dialkyl isoprenoid bisphosphonates as geranylgeranyl diphosphate synthase inhibitors. Bioorg Med Chem. 2008 Jan 1;16(1):390-9. Epub 2007 Sep 18.

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