Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0LL3D
|
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| Former ID |
DNC013439
|
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| Drug Name |
7-bromo-1H-indazole
|
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C7H5BrN2
|
||||
| Canonical SMILES |
C1=CC2=C(C(=C1)Br)NN=C2
|
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| InChI |
1S/C7H5BrN2/c8-6-3-1-2-5-4-9-10-7(5)6/h1-4H,(H,9,10)
|
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| InChIKey |
KMHHWCPTROQUFM-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Nitric-oxide synthase, brain | Target Info | Inhibitor | [1] | |
| BioCyc Pathway | Citrulline-nitric oxide cycle | ||||
| KEGG Pathway | Arginine and proline metabolism | ||||
| Metabolic pathways | |||||
| Calcium signaling pathway | |||||
| Phagosome | |||||
| Circadian entrainment | |||||
| Long-term depression | |||||
| Salivary secretion | |||||
| Alzheimer's disease | |||||
| Amyotrophic lateral sclerosis (ALS) | |||||
| NetPath Pathway | EGFR1 Signaling Pathway | ||||
| PANTHER Pathway | CCKR signaling map ST | ||||
| PathWhiz Pathway | Arginine and Proline Metabolism | ||||
| Reactome | ROS production in response to bacteria | ||||
| Nitric oxide stimulates guanylate cyclase | |||||
| WikiPathways | Monoamine Transport | ||||
| Myometrial Relaxation and Contraction Pathways | |||||
| Amyotrophic lateral sclerosis (ALS) | |||||
| Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis | |||||
| Spinal Cord Injury | |||||
| Alzheimers Disease | |||||
| Effects of Nitric Oxide | |||||
| Serotonin Transporter Activity | |||||
| References | |||||
| REF 1 | Bioorg Med Chem Lett. 2007 Jun 1;17(11):3177-80. Epub 2007 Mar 14.4-substituted indazoles as new inhibitors of neuronal nitric oxide synthase. | ||||
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