Drug General Information
Drug ID	D03LJX
Former ID	DNC010371
Drug Name	(3-amino-5-bromobenzofuran-2-yl)(phenyl)methanone
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[530650]
Structure		Download 2D MOL 3D MOL
Formula	C15H10BrNO2
Canonical SMILES	C1=CC=C(C=C1)C(=O)C2=C(C3=C(O2)C=CC(=C3)Br)N
InChI	1S/C15H10BrNO2/c16-10-6-7-12-11(8-10)13(17)15(19-12)14(18)9-4-2-1-3-5-9/h1-8H,17H2
InChIKey	SBFAYONAJFSEPC-UHFFFAOYSA-N
PubChem Compound ID	651586
Target and Pathway
Target(s)	Adenosine A2a receptor	Target Info	Inhibitor	[530650]
KEGG Pathway	Rap1 signaling pathway
	Calcium signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Vascular smooth muscle contraction
	Parkinson's disease
	Alcoholism
Pathway Interaction Database	HIF-2-alpha transcription factor network
PathWhiz Pathway	Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Reactome	NGF-independant TRKA activation
	Adenosine P1 receptors
	G alpha (s) signalling events
	Surfactant metabolism
WikiPathways	Nucleotide GPCRs
	Monoamine Transport
	GPCRs, Class A Rhodopsin-like
	NGF signalling via TRKA from the plasma membrane
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, Other
References
Ref 530650	J Med Chem. 2010 Feb 25;53(4):1799-809.Structure-based discovery of novel chemotypes for adenosine A(2A) receptor antagonists.
Ref 530650	J Med Chem. 2010 Feb 25;53(4):1799-809.Structure-based discovery of novel chemotypes for adenosine A(2A) receptor antagonists.

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