Drug Information

Drug General Information
Drug ID
D0AT5L
Former ID
DIB018139
Drug Name
[125I]AB-MECA
Synonyms
[125I]5-[6-[(4-aminophenyl)methylamino]purin-9-yl]-3,4-dihydroxy-N-methyl-oxolane-2-carboxamide; [125I]N(6)-(4-amino-3-iodobenzyl)adenosine-5'-N-methyluronamide; [125I]-AB-MECA
Drug Type
Small molecular drug
Indication Discovery agent Investigative [467695]
Structure
Download
2D MOL
Formula
C18H20IN7O4
InChI
InChI=1S/C18H20IN7O4/c1-21-17(29)14-12(27)13(28)18(30-14)26-7-25-11-15(23-6-24-16(11)26)22-5-8-2-3-10(20)9(19)4-8/h2-4,6-7,12-14,18,27-28H,5,20H2,1H3,(H,21,29)(H,22,23,24)/t12-,13+,14-,18+/m0/s1/i19-2
InChIKey
LOGOEBMHHXYBID-WBKNRDRNSA-N
PubChem Compound ID
73754993
PubChem Substance ID
135651100
Target and Pathway
Target(s) Adenosine A3 receptor Target Info Agonist [525758]
Reactome Adenosine P1 receptors
G alpha (i) signalling events
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
GPCRs, Other
References
Ref 467695(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 436).
Ref 525758[(3)H]MRE 3008F20: a novel antagonist radioligand for the pharmacological and biochemical characterization of human A(3) adenosine receptors. Mol Pharmacol. 2000 May;57(5):968-75.

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